PMID- 12356510
OWN - NLM
STAT- MEDLINE
DCOM- 20030212
LR  - 20191106
IS  - 0960-7404 (Print)
IS  - 0960-7404 (Linking)
VI  - 11
IP  - 3
DP  - 2002 Nov
TI  - Multiple endocrine neoplasia type 1: fresh perspective on clinical features and 
      penetrance.
PG  - 143-50
AB  - Multiple endocrine neoplasia type 1 (MEN-1) is an interesting genetic syndrome of 
      polyendocrinopathies. Clinical knowledge about MEN-1 is essential as it appears 
      to be significantly under-diagnosed. New data from several prospective series 
      shows not only that as a many as 40% of patients manifest a first feature of 
      MEN-1 after age 40, but also that as many as a third of gene carriers do not 
      present with hyperparathyroidism as the first feature, as previously believed. 
      Mutational analysis for frequently involved exons of the gene menin on chromosome 
      11 is now available, but negative results should be interpreted with caution in 
      patients with clinical MEN-1. Disease-specific mortality is significant, arises 
      largely from pancreatic islet carcinoma and malignant thymic carcinoid, and 
      renders this disorder worthy of careful and early prospective diagnosis and 
      treatment.
CI  - Copyright 2002 Elsevier Science Ltd.
FAU - Glascock, Matthew J
AU  - Glascock MJ
AD  - Section of Endocrine Surgery, Department of Surgery, University of Pittsburgh 
      School of Medicine, Pittsburgh, Pennsylvania, USA. g1001001@pitt.edu
FAU - Carty, Sally E
AU  - Carty SE
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Surg Oncol
JT  - Surgical oncology
JID - 9208188
SB  - IM
MH  - Humans
MH  - Hyperparathyroidism/etiology
MH  - Mass Screening
MH  - Multiple Endocrine Neoplasia Type 1/complications/*epidemiology/*genetics
MH  - Pancreatic Neoplasms/etiology
MH  - *Penetrance
MH  - Pituitary Neoplasms/etiology
MH  - Population Surveillance
RF  - 56
EDAT- 2002/10/03 04:00
MHDA- 2003/02/14 04:00
CRDT- 2002/10/03 04:00
PHST- 2002/10/03 04:00 [pubmed]
PHST- 2003/02/14 04:00 [medline]
PHST- 2002/10/03 04:00 [entrez]
AID - S0960740401000317 [pii]
AID - 10.1016/s0960-7404(01)00031-7 [doi]
PST - ppublish
SO  - Surg Oncol. 2002 Nov;11(3):143-50. doi: 10.1016/s0960-7404(01)00031-7.