PMID- 12359119
OWN - NLM
STAT- MEDLINE
DCOM- 20030327
LR  - 20191106
IS  - 1529-7322 (Print)
IS  - 1529-7322 (Linking)
VI  - 2
IP  - 6
DP  - 2002 Nov
TI  - Mediators in nasal polyposis.
PG  - 481-7
AB  - Nasal polyposis (NP) is a chronic inflammatory disease of the sinuses often 
      associated with asthma. Although we have not yet achieved a full understanding of 
      the precise mechanisms underlying the pathogenesis of NP, recent insights have 
      been acquired into the regulation of eosinophil chemotaxis, activation, and 
      survival, in addition to their possible link to gross histopathologic changes 
      such as pseudocyst formation. Interleukin (IL)-5, transforming growth 
      factor-beta(1), and eotaxin seem to be crucial players in the regulation of 
      eosinophilic inflammation and extracellular matrix breakdown. The cytokine 
      pattern in NP assumes neither a T helper 1 (Th1) nor Th2 type predominance, 
      because IL-4, IL-5, IL-12, and interferon-gamma have all been shown to be 
      upregulated in NP tissue, without influence of the atopic status. However, recent 
      studies have demonstrated a strong local upregulation of the immunoglobulin E 
      (IgE) synthesis with the formation of specific IgE to Staphylococcus aureus 
      enterotoxins, suggesting a possible role of superantigens in these pathologic 
      processes.
FAU - Bachert, Claus
AU  - Bachert C
AD  - Department of Oto-Rhino-Laryngology, Ghent University Hospital, B-9000 Ghent, 
      Belgium. claus.bachert@rug.ac.be
FAU - Gevaert, Philippe
AU  - Gevaert P
FAU - Holtappels, Gabriele
AU  - Holtappels G
FAU - van Cauwenberge, Paul
AU  - van Cauwenberge P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Allergy Asthma Rep
JT  - Current allergy and asthma reports
JID - 101096440
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Cell Adhesion Molecules/metabolism
MH  - Chemokines/metabolism
MH  - Cytokines/metabolism
MH  - Eosinophilia/immunology
MH  - Eosinophils/immunology
MH  - Humans
MH  - Inflammation Mediators/*metabolism
MH  - Nasal Polyps/*immunology
RF  - 50
EDAT- 2002/10/03 04:00
MHDA- 2003/03/28 05:00
CRDT- 2002/10/03 04:00
PHST- 2002/10/03 04:00 [pubmed]
PHST- 2003/03/28 05:00 [medline]
PHST- 2002/10/03 04:00 [entrez]
AID - 10.1007/s11882-002-0088-9 [doi]
PST - ppublish
SO  - Curr Allergy Asthma Rep. 2002 Nov;2(6):481-7. doi: 10.1007/s11882-002-0088-9.