PMID- 12361531
OWN - NLM
STAT- MEDLINE
DCOM- 20030107
LR  - 20191025
IS  - 0210-5705 (Print)
IS  - 0210-5705 (Linking)
VI  - 25
IP  - 8
DP  - 2002 Oct
TI  - [Variability of the clinical expression of Ecstasy-induced hepatotoxicity].
PG  - 497-500
AB  - 3,4-methylenedioxymethamphetamine (MDMA) is an amphetamine derivative, known as 
      ecstasy. Because of its euphoric effects, the use of this substance as a drug of 
      abuse is becoming increasingly widespread. The development of hyperthermia, 
      disseminated intravascular coagulation, rhabdomyolysis, acute renal failure, 
      cardiac arrhythmia and neurotoxicity have been described in association with the 
      use of this drug. Moreover, in the last few years, cases of liver involvement, 
      associated or not with the above-mentioned entities, have been described, ranging 
      from mild acute hepatitis to fulminant hepatic failure and death. We present four 
      cases of ecstasy-induced hepatotoxicity. Outcome was favorable in three patients 
      while the fourth required liver transplantation. Consequently, ecstasy ingestion 
      should be ruled out as a cause of acute non-viral hepat
FAU - Nunez, O
AU  - Nunez O
AD  - Servicio de Aparato Digestivo, Seccion de Hepatologia, Hospital Universitario 
      Gregorio Maranon, Madrid, Spain.
FAU - Banares, R
AU  - Banares R
FAU - Barrio, J
AU  - Barrio J
FAU - Menchen, L
AU  - Menchen L
FAU - Diego, A de
AU  - Diego Ad
FAU - Salinero, E
AU  - Salinero E
FAU - Clemente, G
AU  - Clemente G
LA  - spa
PT  - Case Reports
PT  - Comparative Study
PT  - Journal Article
TT  - Variabilidad de la expresion clinica de la toxicidad hepatica por extasis.
PL  - Spain
TA  - Gastroenterol Hepatol
JT  - Gastroenterologia y hepatologia
JID - 8406671
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Abdominal Pain/chemically induced
MH  - Adolescent
MH  - Adult
MH  - Biopsy
MH  - Chemical and Drug Induced Liver 
      Injury/blood/diagnosis/*etiology/pathology/surgery
MH  - Cholestasis, Intrahepatic/chemically induced
MH  - Female
MH  - Fever/chemically induced
MH  - Hepatic Encephalopathy/chemically induced
MH  - Humans
MH  - Liver Transplantation
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*adverse effects
MH  - Vomiting/chemically induced
EDAT- 2002/10/04 04:00
MHDA- 2003/01/08 04:00
CRDT- 2002/10/04 04:00
PHST- 2002/10/04 04:00 [pubmed]
PHST- 2003/01/08 04:00 [medline]
PHST- 2002/10/04 04:00 [entrez]
AID - 13037619 [pii]
AID - 10.1016/s0210-5705(02)70299-9 [doi]
PST - ppublish
SO  - Gastroenterol Hepatol. 2002 Oct;25(8):497-500. doi: 
      10.1016/s0210-5705(02)70299-9.