PMID- 12361632
OWN - NLM
STAT- MEDLINE
DCOM- 20030325
LR  - 20190815
IS  - 0142-9612 (Print)
IS  - 0142-9612 (Linking)
VI  - 23
IP  - 24
DP  - 2002 Dec
TI  - Sensitization potential of gold sodium thiosulfate in mice and guinea pigs.
PG  - 4907-14
AB  - Since gold sodium thiosulfate (GST) has been included in a standard patch test 
      series for diagnosis of allergic contact dermatitis from gold, the incidence of 
      patients showing positive reactions to gold is increasing. However, there were 
      little reports on induction of gold sensitization in animals. In this study, we 
      have examined the sensitization potential of GST using mice and guinea pigs. In 
      the guinea pig maximization test, 2 or 6 out of 10 animals showed positive skin 
      responses, mainly edema, by challenge with 2% or 5% GST in 50% ethanol solution, 
      respectively. In the mouse ear swelling test, positive ear swelling (20% greater 
      increase in ear thickness) after challenge with GST was shown in 2 out of 6 mice 
      those previously treated with GST. Topical exposure of mice to GST in 70% 
      dimethylsulfoxide solution induced small increases in the lymph node weight and 
      the lymph node cell (LNC) number in the murine local lymph node assay (LLNA). A 
      greater degree of LNC responses were observed in the sensitive mouse lymph node 
      assay (SLNA) compared with the LLNA, but the stimulation index of total lymph 
      node response by GST was not so high. From these results, GST was identified as a 
      contact allergen, but the sensitization potential was not so strong. In the mouse 
      IgE test, treatment of mice with GST resulted in a statistically significant 
      increase in the serum IgE antibody concentration that associated with 
      immediate-type hypersensitivity reaction. It may suggest that the sensitization 
      responses from gold would appear not only at the contact site but also 
      systematically.
CI  - Copyright 2002 Elsevier Science Ltd.
FAU - Ikarashi, Y
AU  - Ikarashi Y
AD  - Division of Medical Devices, National Institute of Health Sciences, Kamiyoga 
      1-18-1, Setagaya-ku, Tokyo 158-8501, Japan. ikarashi@nihs.go.jp
FAU - Kaniwa, M
AU  - Kaniwa M
FAU - Tsuchiya, T
AU  - Tsuchiya T
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 37341-29-0 (Immunoglobulin E)
RN  - CKS1YQ9W1J (Gold Sodium Thiosulfate)
SB  - IM
MH  - Animals
MH  - Dermatitis, Allergic Contact/diagnosis
MH  - Female
MH  - Gold Sodium Thiosulfate/*pharmacology
MH  - Guinea Pigs
MH  - Immunization
MH  - Immunoglobulin E/immunology/metabolism
MH  - Lymph Nodes/pathology
MH  - Mice
EDAT- 2002/10/04 04:00
MHDA- 2003/03/26 05:00
CRDT- 2002/10/04 04:00
PHST- 2002/10/04 04:00 [pubmed]
PHST- 2003/03/26 05:00 [medline]
PHST- 2002/10/04 04:00 [entrez]
AID - S0142961202002508 [pii]
AID - 10.1016/s0142-9612(02)00250-8 [doi]
PST - ppublish
SO  - Biomaterials. 2002 Dec;23(24):4907-14. doi: 10.1016/s0142-9612(02)00250-8.