PMID- 12361849
OWN - NLM
STAT- MEDLINE
DCOM- 20021129
LR  - 20231213
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 331
IP  - 2
DP  - 2002 Oct 11
TI  - Effects of nociceptin (13-17) in pain modulation at supraspinal level in mice.
PG  - 95-8
AB  - This work was designed to observe the effects of nociceptin(13-17), one of the 
      main metabolites of nociceptin (also termed orphanin FQ), in pain modulation at 
      supraspinal level in mice. Intracerebroventricular (i.c.v.) administration of 
      nociceptin/orphanin FQ(13-17) (N/OFQ(13-17)) (5, 0.5, 0.05, 0.005 nmol/mouse) 
      dose-dependently induced potent hyperalgesic effects in the 48 degrees C 
      warm-water tail-flick test in mice. I.c.v. pretreatment with N/OFQ(13-17) (5, 
      0.5, 0.05 nmol/mouse) potentiated the analgesic effects induced by morphine 
      (i.p., 2 mg/kg) and reversed the hyperalgesic effects induced by N/OFQ (i.c.v., 5 
      nmol/mouse). The hyperalgesic effects induced by N/OFQ(13-17) could not be 
      antagonized by [Nphe((1))]N/OFQ(1-13)NH((2)) or naloxone. These findings suggest 
      that N/OFQ(13-17) may play important roles in pain modulation at supraspinal 
      level in mice and elicits these effects through a novel mechanism independent of 
      the N/OFQ receptor and the mu, delta and kappa opioid receptors.
FAU - Chen, Li-Xiang
AU  - Chen LX
AD  - Department of Biochemistry and Molecular Biology, School of Life Science, Lanzhou 
      University, 298 Tian Shui Road, 730000, Peoples Republic of, Lanzhou, China.
FAU - Wang, Zhuan-Zi
AU  - Wang ZZ
FAU - Wu, Hua
AU  - Wu H
FAU - Fang, Quan
AU  - Fang Q
FAU - Chen, Yong
AU  - Chen Y
FAU - Wang, Rui
AU  - Wang R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Opioid Peptides)
RN  - 0 (Peptide Fragments)
RN  - 0 (Vasodilator Agents)
RN  - 0 (nociceptin (1-13) amide)
RN  - 36B82AMQ7N (Naloxone)
RN  - 73674-85-8 (naloxazone)
RN  - 76I7G6D29C (Morphine)
SB  - IM
MH  - Analgesia
MH  - Analgesics, Opioid/administration & dosage/pharmacology
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Hot Temperature
MH  - Hyperalgesia/*chemically induced/physiopathology
MH  - Injections, Intraventricular
MH  - Male
MH  - Mice
MH  - Morphine/administration & dosage/pharmacology
MH  - Naloxone/administration & dosage/*analogs & derivatives/pharmacology
MH  - Opioid Peptides/administration & dosage/*pharmacology
MH  - Pain Measurement
MH  - Peptide Fragments/administration & dosage/*pharmacology
MH  - Vasodilator Agents/administration & dosage/*pharmacology
MH  - Nociceptin
EDAT- 2002/10/04 04:00
MHDA- 2002/11/30 04:00
CRDT- 2002/10/04 04:00
PHST- 2002/10/04 04:00 [pubmed]
PHST- 2002/11/30 04:00 [medline]
PHST- 2002/10/04 04:00 [entrez]
AID - S0304394002008443 [pii]
AID - 10.1016/s0304-3940(02)00844-3 [doi]
PST - ppublish
SO  - Neurosci Lett. 2002 Oct 11;331(2):95-8. doi: 10.1016/s0304-3940(02)00844-3.