PMID- 12363467
OWN - NLM
STAT- MEDLINE
DCOM- 20021209
LR  - 20220408
IS  - 0145-2126 (Print)
IS  - 0145-2126 (Linking)
VI  - 26
IP  - 11
DP  - 2002 Nov
TI  - Comparison of cytogenetics with FISH in 40 myelodysplastic syndrome patients.
PG  - 993-6
AB  - Karyotyping is important for diagnosis and prognosis of myelodysplastic syndrome 
      (MDS). Using fluorescence in situ hybridization (FISH) either mitotic or 
      interphase cells can be analyzed and a higher number of cells can be screened. 
      This study evaluated the effectiveness of FISH in detecting the most common 
      chromosomal abnormalities [-5/del 5q/-7/+8/del 11q23 and -Y] in 40 patients with 
      MDS. Karyotype detected abnormalities in 35.2% of the patients and FISH in 35%, 
      while some abnormalities remained undetected by each approach but the association 
      of both methods increased the detection rate up to 40%.
FAU - Romeo, Maura
AU  - Romeo M
AD  - Disciplina de Hematologia e Hemoterapia, Rua Botucatu 740, 3.o Andar, 04023-900, 
      UNIFESP/EPM, SP, Sao Paulo, Brazil
FAU - Chauffaille, Maria de Lourdes
AU  - Chauffaille Mde L
FAU - Silva, Maria Regina R
AU  - Silva MR
FAU - Bahia, Daniella M M
AU  - Bahia DM
FAU - Kerbauy, Jose
AU  - Kerbauy J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - *Chromosome Aberrations
MH  - Chromosome Deletion
MH  - Chromosomes, Human, Pair 11/genetics
MH  - Chromosomes, Human, Pair 5/genetics
MH  - Chromosomes, Human, Pair 7/genetics
MH  - Cytogenetic Analysis/methods/*standards
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Karyotyping
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/diagnosis/*genetics/mortality
MH  - Prognosis
EDAT- 2002/10/05 04:00
MHDA- 2002/12/10 04:00
CRDT- 2002/10/05 04:00
PHST- 2002/10/05 04:00 [pubmed]
PHST- 2002/12/10 04:00 [medline]
PHST- 2002/10/05 04:00 [entrez]
AID - S0145212602000474 [pii]
AID - 10.1016/s0145-2126(02)00047-4 [doi]
PST - ppublish
SO  - Leuk Res. 2002 Nov;26(11):993-6. doi: 10.1016/s0145-2126(02)00047-4.