PMID- 12364436
OWN - NLM
STAT- MEDLINE
DCOM- 20021030
LR  - 20161124
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 87
IP  - 10
DP  - 2002 Oct
TI  - Neurotrophin-4/5 and neurotrophin-3 are present within the human ovarian follicle 
      but appear to have different paracrine/autocrine functions.
PG  - 4569-71
AB  - Neurotrophins are a family of soluble polypeptide growth factors widely 
      recognized for their role in the mammalian nervous system. We first reported the 
      unique presence of one neurotrophin, brain-derived neurotrophic factor (BDNF), in 
      the follicular fluid of the human ovarian follicle. The BDNF receptor, Trk B, was 
      identified in mouse oocytes, and BDNF accelerated first polar body extrusion in 
      vitro. In the present study, we examined human follicular fluid and mouse 
      immature oocytes to determine whether another Trk B ligand, neurotrophin-4/5 
      (NT-4/5), is present within the ovarian follicle and if so, whether it 
      demonstrates activity similar to that of BDNF. We also examined whether a non-Trk 
      B neurotrophin ligand, neurotrophin-3 (NT-3), is present within the follicle and 
      has a possible role in oocyte maturation. NT-4/5 and NT-3 were noted to be 
      present in all human follicular fluid samples aspirated from follicles of women 
      undergoing in vitro fertilization. NT-4/5, but not NT-3, significantly promoted 
      mouse oocyte polar body extrusion. Trk C receptors were not noted to be present 
      in mouse oocytes. This study demonstrates for the first time that NT-4/5 and NT-3 
      are present in the follicular fluid of the human ovary. These data suggest that 
      NT-4/5, like BDNF, promotes oocyte nuclear maturation. In contrast, NT-3 does not 
      promote oocyte maturation but may contribute to follicle-oocyte maturation by 
      mechanisms not yet identified.
FAU - Seifer, David B
AU  - Seifer DB
AD  - Department of Obstetrics, University of Medicine and Dentistry of New 
      Jersey-Robert Wood Johnson Medical School, New Brunswick, New Jersey 08901, USA. 
      seiferdb@umdnj.edu
FAU - Feng, Bo
AU  - Feng B
FAU - Shelden, Robert M
AU  - Shelden RM
FAU - Chen, Shiling
AU  - Chen S
FAU - Dreyfus, Cheryl F
AU  - Dreyfus CF
LA  - eng
GR  - AG 15425/AG/NIA NIH HHS/United States
GR  - HD 23315/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurotrophin 3)
RN  - 145172-44-7 (neurotrophin 5)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Female
MH  - Follicular Fluid/chemistry
MH  - Humans
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Nerve Growth Factors/analysis/pharmacology/*physiology
MH  - Neurotrophin 3/analysis/pharmacology/*physiology
MH  - Oocytes/drug effects/physiology
MH  - Ovarian Follicle/*chemistry
EDAT- 2002/10/05 04:00
MHDA- 2002/11/01 04:00
CRDT- 2002/10/05 04:00
PHST- 2002/10/05 04:00 [pubmed]
PHST- 2002/11/01 04:00 [medline]
PHST- 2002/10/05 04:00 [entrez]
AID - 10.1210/jc.2002-020499 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2002 Oct;87(10):4569-71. doi: 10.1210/jc.2002-020499.