PMID- 12366779
OWN - NLM
STAT- MEDLINE
DCOM- 20030725
LR  - 20190826
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 60
IP  - 1
DP  - 2002 Jul
TI  - A MAGE-3 peptide presented by HLA-B44 is also recognized by cytolytic T 
      lymphocytes on HLA-B18.
PG  - 16-24
AB  - Antigens encoded by MAGE genes are of particular interest for cancer 
      immunotherapy because of their tumoral specificity and because they are shared by 
      many tumors. Antigenic peptide MEVDPIGHLY, which is encoded by MAGE-3 and is 
      known to be presented by human leukocyte antigen (HLA)-B44, is currently being 
      used in therapeutic vaccination trials. We report here that a cytolytic T 
      lymphocyte (CTL) clone, which is restricted by HLA-B*1801, recognizes the same 
      peptide and, importantly, lyzes HLA-B18 tumor cells expressing MAGE-3. These 
      results imply that the use of peptide MEVDPIGHLY can now be extended to HLA-B18 
      patients. We also provide evidence that, under limiting amounts of protein 
      MAGE-3, HLA B*1801 and B*4403 compete for binding to the peptide.
FAU - Bilsborough, J
AU  - Bilsborough J
AD  - Immunex Corperation, Seattle, WA, USA.
FAU - Panichelli, C
AU  - Panichelli C
FAU - Duffour, M-T
AU  - Duffour MT
FAU - Warnier, G
AU  - Warnier G
FAU - Lurquin, C
AU  - Lurquin C
FAU - Schultz, E S
AU  - Schultz ES
FAU - Thielemans, K
AU  - Thielemans K
FAU - Corthals, J
AU  - Corthals J
FAU - Boon, T
AU  - Boon T
FAU - van der Bruggen, P
AU  - van der Bruggen P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B18 Antigen)
RN  - 0 (HLA-B44 Antigen)
RN  - 0 (MAGEA3 protein, human)
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - Antigen Presentation/*physiology
MH  - Antigens, Neoplasm/isolation & purification/*metabolism
MH  - B-Lymphocytes/metabolism/virology
MH  - CD8-Positive T-Lymphocytes/*metabolism/virology
MH  - Cell Transformation, Viral
MH  - Clone Cells/chemistry/immunology/virology
MH  - Dendritic Cells/metabolism/virology
MH  - HLA-B Antigens/*metabolism
MH  - HLA-B18 Antigen
MH  - HLA-B44 Antigen
MH  - Herpesvirus 4, Human/metabolism
MH  - Humans
MH  - Lymphocyte Activation
MH  - Neoplasm Proteins/isolation & purification/*metabolism
MH  - Tumor Cells, Cultured
EDAT- 2002/10/09 04:00
MHDA- 2003/07/26 05:00
CRDT- 2002/10/09 04:00
PHST- 2002/10/09 04:00 [pubmed]
PHST- 2003/07/26 05:00 [medline]
PHST- 2002/10/09 04:00 [entrez]
AID - tan600103 [pii]
AID - 10.1034/j.1399-0039.2002.600103.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2002 Jul;60(1):16-24. doi: 10.1034/j.1399-0039.2002.600103.x.