PMID- 12366781
OWN - NLM
STAT- MEDLINE
DCOM- 20030725
LR  - 20190826
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 60
IP  - 1
DP  - 2002 Jul
TI  - Association of single nucleotide polymorphisms in the IL-18 gene with sarcoidosis 
      in a Japanese population.
PG  - 36-42
AB  - Interleukin-18 (IL-18) and interleukin-12 (IL-12) synergistically stimulate 
      interferon-gamma (IFN-gamma) production from Th1 cells. The levels of serum IL-18 
      and IFN-gamma and bronchoalveolar lavage fluid IL-18 were elevated in patients 
      with sarcoidosis. The polymorphisms of the IL-18 gene may play a possible role in 
      expression regulation of the gene. We investigated the roles of the polymorphisms 
      in the development of sarcoidosis. We examined two single nucleotide 
      polymorphisms of the IL-18 gene in 119 patients with sarcoidosis and 130 healthy 
      control subjects. Our results showed that the frequency of sarcoidosis patients 
      with the CA genotype at position -607 was significantly higher than that with the 
      AA genotype (OR = 2.200) and a significantly higher proportion of patients had 
      the C allele at -607 compared with that of the controls (OR = 2.123). No 
      significant differences were seen in the distribution of the genotypes or 
      phenotype frequencies at position -137. There was no specific organ involvement 
      associated with a certain genotype or phenotype. In IL-18 gene polymorphisms, the 
      C allele at position -607 might be a genetic risk factor for sarcoidosis in this 
      Japanese population.
FAU - Takada, T
AU  - Takada T
AD  - Division of Respiratory Medicine, Graduate School of Medical and Dental Sciences, 
      Niigata University, Niigata, Japan. ttakada@med.niigata-u.ac.jp
FAU - Suzuki, E
AU  - Suzuki E
FAU - Morohashi, K
AU  - Morohashi K
FAU - Gejyo, F
AU  - Gejyo F
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Genetic Markers)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Female
MH  - Genetic Markers/genetics
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Japan/epidemiology
MH  - Linkage Disequilibrium/genetics
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Sarcoidosis, Pulmonary/*genetics
MH  - Statistics as Topic
EDAT- 2002/10/09 04:00
MHDA- 2003/07/26 05:00
CRDT- 2002/10/09 04:00
PHST- 2002/10/09 04:00 [pubmed]
PHST- 2003/07/26 05:00 [medline]
PHST- 2002/10/09 04:00 [entrez]
AID - tan600105 [pii]
AID - 10.1034/j.1399-0039.2002.600105.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2002 Jul;60(1):36-42. doi: 10.1034/j.1399-0039.2002.600105.x.