PMID- 12368416
OWN - NLM
STAT- MEDLINE
DCOM- 20021029
LR  - 20231213
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 132
IP  - 10
DP  - 2002 Oct
TI  - Soy isoflavones increase latency of spontaneous mammary tumors in mice.
PG  - 3186-90
AB  - Soy protein, with and without isoflavones, is being added to foods by 
      manufacturers in response to the Food and Drug Administration (FDA)-approved 
      health claim for cardiovascular protection. Furthermore, soy isoflavones are 
      increasingly consumed by women in the United States as an alternative to hormone 
      replacement therapy. The role of these phytoestrogens in breast cancer is 
      controversial. Although exposure of rodents to soy isoflavones during the 
      perinatal period appears to reduce mammary cancer formation, exposure in utero or 
      during adulthood may increase tumor growth. The mouse mammary tumor virus 
      (MMTV)-neu mouse spontaneously develops mammary tumors due to overexpression of 
      the ErbB-2/neu/HER2 oncogene. This model is comparable with human breast cancer 
      because overexpression of the neu oncogene occurs in 20-40% of human breast 
      cancers. We fed MMTV-neu mice AIN-93G diets containing no isoflavones, 250 mg/kg 
      genistein, 250 mg/kg daidzein or an isoflavone mixture (NovaSoy, equivalent to 
      250 mg genistein/kg) from 7 wk of age. Mammary tumor latency was significantly 
      delayed in mice fed isoflavones compared with the control. Once tumors formed, 
      however, the isoflavones did not reduce the number or size of tumors such that at 
      34 wk of age there were no differences in tumor burden among the treatment 
      groups. Hence, in the MMTV-neu mouse, soy isoflavones delayed mammary 
      tumorigenesis. Further studies are warranted to define the cellular mechanisms 
      through which these compounds affect mammary tumorigenesis in this model.
FAU - Jin, Zeming
AU  - Jin Z
AD  - Genetics Area Program and Food Science and Human Nutrition, University of 
      Missouri, Columbia 65211, USA.
FAU - MacDonald, Ruth S
AU  - MacDonald RS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Isoflavones)
RN  - 0 (Soybean Proteins)
RN  - 6287WC5J2L (daidzein)
RN  - DH2M523P0H (Genistein)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
SB  - IM
MH  - Animals
MH  - Breast Neoplasms/prevention & control
MH  - Female
MH  - Genes, erbB-2
MH  - Genistein/administration & dosage/pharmacology
MH  - Humans
MH  - Isoflavones/*administration & dosage/pharmacology
MH  - Mammary Neoplasms, Experimental/chemically induced/*prevention & control
MH  - Mammary Tumor Virus, Mouse
MH  - Mice
MH  - Mice, Transgenic
MH  - Random Allocation
MH  - Receptor, ErbB-2/genetics
MH  - Soybean Proteins/administration & dosage/*pharmacology
MH  - Glycine max/chemistry
EDAT- 2002/10/09 04:00
MHDA- 2002/10/31 04:00
CRDT- 2002/10/09 04:00
PHST- 2002/10/09 04:00 [pubmed]
PHST- 2002/10/31 04:00 [medline]
PHST- 2002/10/09 04:00 [entrez]
AID - 10.1093/jn/131.10.3186 [doi]
PST - ppublish
SO  - J Nutr. 2002 Oct;132(10):3186-90. doi: 10.1093/jn/131.10.3186.