PMID- 12368474
OWN - NLM
STAT- MEDLINE
DCOM- 20021204
LR  - 20181113
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 99
IP  - 21
DP  - 2002 Oct 15
TI  - Tau filament formation and associative memory deficit in aged mice expressing 
      mutant (R406W) human tau.
PG  - 13896-901
AB  - The R406W tau mutation found in frontotemporal dementia and parkinsonism linked 
      to chromosome 17 (FTDP-17) causes a hereditary tauopathy clinically resembling 
      Alzheimer's disease. Expression of modest levels of the longest human tau isoform 
      with this mutation under the control of the alpha-calcium-calmodulin-dependent 
      kinase-II promoter in transgenic (Tg) mice resulted in the development of 
      congophilic hyperphosphorylated tau inclusions in forebrain neurons. These 
      inclusions appeared as early as 18 months of age. As with human cases, tau 
      inclusions were composed of both mutant and endogenous wild-type tau, and were 
      associated with microtubule disruption and flame-shaped transformations of the 
      affected neurons. Straight tau filaments were recovered from Sarkosyl-insoluble 
      fractions from only the aged Tg brains. Behaviorally, aged Tg mice had 
      associative memory impairment without obvious sensorimotor deficits. Therefore, 
      these mice that exhibit a phenotype mimicking R406W FTDP-17 provide an animal 
      model for investigating the adverse properties associated with this mutation, 
      which might potentially recapitulate some etiological events in Alzheimer's 
      disease.
FAU - Tatebayashi, Yoshitaka
AU  - Tatebayashi Y
AD  - Laboratory for Alzheimer's Disease and Neural Architecture, Brain Science 
      Institute, Institute of Physical and Chemical Research (RIKEN), 2-1 Hirosawa, 
      Wako-shi, Saitama 351-0198, Japan.
FAU - Miyasaka, Tomohiro
AU  - Miyasaka T
FAU - Chui, De-Hua
AU  - Chui DH
FAU - Akagi, Takumi
AU  - Akagi T
FAU - Mishima, Ken-ichi
AU  - Mishima K
FAU - Iwasaki, Katsunori
AU  - Iwasaki K
FAU - Fujiwara, Michihiro
AU  - Fujiwara M
FAU - Tanemura, Kentaro
AU  - Tanemura K
FAU - Murayama, Miyuki
AU  - Murayama M
FAU - Ishiguro, Koichi
AU  - Ishiguro K
FAU - Planel, Emmanuel
AU  - Planel E
FAU - Sato, Shinji
AU  - Sato S
FAU - Hashikawa, Tsutomu
AU  - Hashikawa T
FAU - Takashima, Akihiko
AU  - Takashima A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20021004
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Recombinant Proteins)
RN  - 0 (tau Proteins)
SB  - IM
MH  - Aging/genetics/metabolism/psychology
MH  - Alzheimer Disease/genetics/metabolism/psychology
MH  - Animals
MH  - Association Learning/physiology
MH  - Disease Models, Animal
MH  - Gene Expression
MH  - Humans
MH  - Inclusion Bodies/metabolism/pathology
MH  - Memory Disorders/*genetics/metabolism/*psychology
MH  - Mice
MH  - Mice, Transgenic
MH  - Neurofibrillary Tangles/metabolism/pathology
MH  - Phenotype
MH  - Point Mutation
MH  - Prosencephalon/metabolism/pathology
MH  - Recombinant Proteins/chemistry/genetics/metabolism
MH  - tau Proteins/chemistry/*genetics/*metabolism
PMC - PMC129794
EDAT- 2002/10/09 04:00
MHDA- 2002/12/05 04:00
PMCR- 2003/04/15
CRDT- 2002/10/09 04:00
PHST- 2002/10/09 04:00 [pubmed]
PHST- 2002/12/05 04:00 [medline]
PHST- 2002/10/09 04:00 [entrez]
PHST- 2003/04/15 00:00 [pmc-release]
AID - 202205599 [pii]
AID - 2055 [pii]
AID - 10.1073/pnas.202205599 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13896-901. doi: 
      10.1073/pnas.202205599. Epub 2002 Oct 4.