PMID- 12368701
OWN - NLM
STAT- MEDLINE
DCOM- 20021107
LR  - 20190916
IS  - 1077-4114 (Print)
IS  - 1077-4114 (Linking)
VI  - 24
IP  - 7
DP  - 2002 Oct
TI  - Successful matched-unrelated bone marrow transplantation in a patient with 
      beta-thalassemia major.
PG  - 579-81
AB  - The authors describe a 5-year-old boy with beta-thalassemia major who received 
      bone marrow transplantation (BMT) from a human leukocyte antigen (HLA)-matched 
      unrelated donor. The conditioning regimen consisted of 16 mg/kg busulfan and 200 
      mg/kg cyclophosphamide. The transplantation was complicated with grade II 
      graft-versus-host disease, although prophylaxis with cyclosporine and short-term 
      methotrexate was carried out. Cytomegalovirus disease occurred at 2 months after 
      transplantation but was controlled successfully. The child remains disease-free 
      and in good clinical condition 53 months after BMT. The authors suggest that BMT 
      from an HLA-matched unrelated donor could be considered as an alternative 
      treatment in patients with beta-thalassemia major when no HLA-matched donor is 
      available.
FAU - Cheng, Chao-Neng
AU  - Cheng CN
AD  - Department of Pediatrics, National Cheng Kung University Hospital, Tainan, 
      Taiwan.
FAU - Lu, Cheng-Chan
AU  - Lu CC
FAU - Sun, Hsiao-Fang Sunny
AU  - Sun HF
FAU - Su, Wu-Chou
AU  - Su WC
FAU - Chen, Jiann-Shiuh
AU  - Chen JS
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pediatr Hematol Oncol
JT  - Journal of pediatric hematology/oncology
JID - 9505928
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Bone Marrow/immunology/metabolism
MH  - Bone Marrow Transplantation/*immunology
MH  - Child, Preschool
MH  - Female
MH  - Genotype
MH  - HLA Antigens/genetics/immunology
MH  - Humans
MH  - Male
MH  - Tissue Donors
MH  - beta-Thalassemia/*immunology/*therapy
EDAT- 2002/10/09 04:00
MHDA- 2002/11/26 04:00
CRDT- 2002/10/09 04:00
PHST- 2002/10/09 04:00 [pubmed]
PHST- 2002/11/26 04:00 [medline]
PHST- 2002/10/09 04:00 [entrez]
AID - 10.1097/00043426-200210000-00019 [doi]
PST - ppublish
SO  - J Pediatr Hematol Oncol. 2002 Oct;24(7):579-81. doi: 
      10.1097/00043426-200210000-00019.