PMID- 12369708
OWN - NLM
STAT- MEDLINE
DCOM- 20021030
LR  - 20191106
IS  - 1560-4284 (Print)
IS  - 1560-4284 (Linking)
VI  - 2
IP  - 3
DP  - 2001
TI  - Brain-derived neurotrophic factor regulates energy expenditure through the 
      central nervous system in obese diabetic mice.
PG  - 201-9
AB  - It has been previously demonstrated that brain-derived neurotrophic factor (BDNF) 
      regulates glucose metabolism and energy expenditure in rodent diabetic models 
      such as C57BL/KsJ-lepr(db)/lepr(db) (db/db) mice. Central administration of BDNF 
      has been found to reduce blood glucose in db/db mice, suggesting that BDNF acts 
      through the central nervous system. In the present study we have expanded these 
      investigations to explore the effect of central administration of BDNF on energy 
      metabolism. Intracerebroventricular administration of BDNF lowered blood glucose 
      and increased pancreatic insulin content of db/db mice compared with 
      vehicle-treated pellet pair-fed db/db mice. While body temperatures of the pellet 
      pair-fed db/db mice given vehicle were reduced because of restricted food supply 
      in this pair-feeding condition, BDNF treatment remarkably alleviated the 
      reduction of body temperature suggesting the enhancement of thermogenesis. BDNF 
      enhanced norepinephrine turnover and increased uncoupling protein-1 mRNA 
      expression in the interscapular brown adipose tissue. Our evidence indicates that 
      BDNF activates the sympathetic nervous system via the central nervous system and 
      regulates energy expenditure in obese diabetic animals.
FAU - Nonomura, T
AU  - Nonomura T
AD  - Sumitomo Pharmaceuticals Co. Ltd., Discovery Research Laboratories II, Osaka, 
      Japan.
FAU - Tsuchida, A
AU  - Tsuchida A
FAU - Ono-Kishino, M
AU  - Ono-Kishino M
FAU - Nakagawa, T
AU  - Nakagawa T
FAU - Taiji, M
AU  - Taiji M
FAU - Noguchi, H
AU  - Noguchi H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Int J Exp Diabetes Res
JT  - International journal of experimental diabetes research
JID - 100962067
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Insulin)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - Animals
MH  - Body Temperature Regulation
MH  - Brain-Derived Neurotrophic Factor/administration & dosage/*pharmacology
MH  - Cerebral Ventricles/drug effects/physiology/physiopathology
MH  - Diabetes Mellitus/*physiopathology
MH  - Diabetes Mellitus, Type 2/metabolism/*physiopathology
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Energy Metabolism/*drug effects
MH  - Humans
MH  - Injections, Intraventricular
MH  - Insulin/blood
MH  - Islets of Langerhans/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Obese
MH  - *Obesity
MH  - Recombinant Proteins/administration & dosage/pharmacology
MH  - Reference Values
MH  - Skin Temperature/physiology
MH  - Time Factors
PMC - PMC2478552
EDAT- 2002/10/09 04:00
MHDA- 2002/11/01 04:00
PMCR- 2001/01/01
CRDT- 2002/10/09 04:00
PHST- 2002/10/09 04:00 [pubmed]
PHST- 2002/11/01 04:00 [medline]
PHST- 2002/10/09 04:00 [entrez]
PHST- 2001/01/01 00:00 [pmc-release]
AID - S1687521401000265 [pii]
AID - 10.1155/edr.2001.201 [doi]
PST - ppublish
SO  - Int J Exp Diabetes Res. 2001;2(3):201-9. doi: 10.1155/edr.2001.201.