PMID- 12369792
OWN - NLM
STAT- MEDLINE
DCOM- 20030507
LR  - 20220317
IS  - 0884-0431 (Print)
IS  - 0884-0431 (Linking)
VI  - 17
IP  - 10
DP  - 2002 Oct
TI  - Three-dimensional-line skeleton graph analysis of high-resolution magnetic 
      resonance images: a validation study from 34-microm-resolution microcomputed 
      tomography.
PG  - 1883-95
AB  - The resolution achievable in vivo by magnetic resonance imaging (MRI) techniques 
      is not sufficient to depict precisely individual trabeculae and, thus, does not 
      permit the quantification of the "true" trabecular bone morphology and topology. 
      Nevertheless, the characterization of the "apparent" trabecular bone network 
      derived from high-resolution MR images (MRIs) and their potential to provide 
      information in addition to bone mineral density (BMD) alone has been established 
      in studies of osteoporosis. The aim of this work was to show the ability of the 
      three-dimensional-line skeleton graph analysis (3D-LSGA) to characterize 
      high-resolution MRIs of trabecular bone structure. Fifteen trabecular bone 
      samples of the distal radius were imaged using the high-resolution MRI (156 x 156 
      x 300 microm3) and microcomputed tomography (microCT; 34 x 34 x 34 microm3). 
      After thresholding, the 3D skeleton graph of each binary image was obtained. To 
      remove the assimilated-noise branches of the skeleton graph and smooth this 
      skeleton graph before it was analyzed, we defined a smoothing length criterion 
      (l(c)), such that all "termini" branches having a length lower than l(c) were 
      removed. Local topological and morphological LSGA measurements were performed 
      from MRIs and microCT images of the same samples. The correlations between these 
      two sets of measurements were dependent on the smoothing criterion l(c), reaching 
      R2 = 0.85 for topological measurements and R2 = 0.57-0.64 for morphological 
      measurements. 3D-LSGA technique could be applied to in vivo high-resolution MRIs 
      of trabecular bone structure, giving an indirect characterization of the 
      microtrabecular bone network.
FAU - Pothuaud, Laurent
AU  - Pothuaud L
AD  - Magnetic Resonance Science Center, Department of Radiology, University of 
      California, San Francisco, 94143-1290, USA.
FAU - Laib, Andres
AU  - Laib A
FAU - Levitz, Pierre
AU  - Levitz P
FAU - Benhamou, Claude L
AU  - Benhamou CL
FAU - Majumdar, Sharmila
AU  - Majumdar S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
PL  - England
TA  - J Bone Miner Res
JT  - Journal of bone and mineral research : the official journal of the American 
      Society for Bone and Mineral Research
JID - 8610640
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Algorithms
MH  - Cluster Analysis
MH  - *Computer Graphics
MH  - Humans
MH  - Image Processing, Computer-Assisted/*methods
MH  - Imaging, Three-Dimensional/*methods
MH  - *Magnetic Resonance Imaging
MH  - Middle Aged
MH  - Radius/*anatomy & histology/diagnostic imaging
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2002/10/09 04:00
MHDA- 2003/05/08 05:00
CRDT- 2002/10/09 04:00
PHST- 2002/10/09 04:00 [pubmed]
PHST- 2003/05/08 05:00 [medline]
PHST- 2002/10/09 04:00 [entrez]
AID - 10.1359/jbmr.2002.17.10.1883 [doi]
PST - ppublish
SO  - J Bone Miner Res. 2002 Oct;17(10):1883-95. doi: 10.1359/jbmr.2002.17.10.1883.