PMID- 1237124
OWN - NLM
STAT- MEDLINE
DCOM- 19751230
LR  - 20190726
IS  - 0031-6768 (Print)
IS  - 0031-6768 (Linking)
VI  - 359
IP  - 4
DP  - 1975 Sep 29
TI  - Metabolic changes in the quadriceps femoris muscle of obese people. Enzyme 
      activity patterns of energy-supplying metabolism.
PG  - 325-34
AB  - 1. In biopsy samples of the lateral part of m. quadriceps femoris of 49 obese and 
      14 lean persons the activities of the following enzymes were investigated: 
      triosephosphate dehydrogenase (TPDH), glycerolphosphate: nad dehydrogenase 
      (GPDH), lactate dehydrogenase (LDH), hexokinase (HK), malate: NAD dehydrogenase 
      (MDH), citrate synthase (CS) and hydroxyacyl-CoA dehydrogenase (HOADH). 2. The 
      muscles of obese had an increased activity ratio of TPDH to CS and to HK, 
      respectively, caused in muscles of female obese subjects by an increase of TPDH 
      activity, in those of obese men rather by a decrease of CS and HK activities. 3. 
      Cluster analysis brough to light the existence of three major groups. Group 1 
      (low activity-low LDH group), consisting of muscles of female obese subjects 
      only, exhibited low activities of all enzymes investigated, that of LDH being so 
      low as to possibly induce a serious deficiency of anerobic metabolism under 
      working conditions. Group 2 (medium enzyme activity group) was characterized by 
      medium enzyme activities, similar to that of lean controls (included in this 
      group). This consisted of subjects of both sex. Group 3 (high enzyme activity 
      group) consisted of obese of both sex. It was distinguished by high enzyme 
      activities, especially of LDH. It is suggested that the groups of similar enzyme 
      activity patterns might reflect different stages, types and/or genesis of 
      obesity.
FAU - Bass, A
AU  - Bass A
FAU - Vondra, K
AU  - Vondra K
FAU - Rath, R
AU  - Rath R
FAU - Vitek, V
AU  - Vitek V
FAU - Havranek, T
AU  - Havranek T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Germany
TA  - Pflugers Arch
JT  - Pflugers Archiv : European journal of physiology
JID - 0154720
RN  - 0 (Hydroxy Acids)
RN  - EC 1.1.- (Alcohol Oxidoreductases)
RN  - EC 1.1.- (Glycerolphosphate Dehydrogenase)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - EC 1.1.1.37 (Malate Dehydrogenase)
RN  - EC 1.2.1.- (Glyceraldehyde-3-Phosphate Dehydrogenases)
RN  - EC 2.3.3.1 (Citrate (si)-Synthase)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - SAA04E81UX (Coenzyme A)
SB  - IM
MH  - Alcohol Oxidoreductases/analysis
MH  - Citrate (si)-Synthase/analysis
MH  - Coenzyme A
MH  - Energy Metabolism
MH  - Female
MH  - Glyceraldehyde-3-Phosphate Dehydrogenases/analysis
MH  - Glycerolphosphate Dehydrogenase/analysis
MH  - Hexokinase/analysis
MH  - Humans
MH  - Hydroxy Acids
MH  - L-Lactate Dehydrogenase/analysis
MH  - Malate Dehydrogenase/analysis
MH  - Male
MH  - Muscles/enzymology/*metabolism
MH  - Obesity/enzymology/*metabolism
MH  - Sex Factors
EDAT- 1975/09/29 00:00
MHDA- 1975/09/29 00:01
CRDT- 1975/09/29 00:00
PHST- 1975/09/29 00:00 [pubmed]
PHST- 1975/09/29 00:01 [medline]
PHST- 1975/09/29 00:00 [entrez]
AID - 10.1007/BF00581443 [doi]
PST - ppublish
SO  - Pflugers Arch. 1975 Sep 29;359(4):325-34. doi: 10.1007/BF00581443.