PMID- 12371690
OWN - NLM
STAT- MEDLINE
DCOM- 20030403
LR  - 20190702
IS  - 0042-4900 (Print)
IS  - 0042-4900 (Linking)
VI  - 151
IP  - 12
DP  - 2002 Sep 21
TI  - Effects of different us isolates of porcine reproductive and respiratory syndrome 
      virus (PRRSV) on blood and bone marrow parameters of experimentally infected 
      pigs.
PG  - 344-8
AB  - Seventy five-week-old, crossbred, caesarean-derived, colostrum-deprived pigs were 
      randomly divided into five groups of 14 pigs and assigned one of five treatments: 
      the intranasal inoculation of 1 (5.7) TCID50 of one of four plaque-purified 
      isolates of porcine reproductive and respiratory syndrome virus (PRRSV) (VR2385, 
      VR2431, ISU-984 and ISU-22), or uninfected cell culture and media. Haematological 
      variables were measured for 21 days and bone marrow was analysed when the pigs 
      were killed three, seven, 10, 21 or 28 days after the inoculation. The 
      PRRSV-infected pigs had non-regenerative anaemia and markedly increased 
      myeloid:erythroid ratios from three to 21 days after inoculation. There was a 
      significant (P < 0.05) difference in the severity of the anaemia induced by the 
      four PRRSV isolates; the most highly pneumovirulent strains (VR2385, ISU-984 and 
      ISU-22) induced more severe anaemia than the least virulent isolate (VR2431). The 
      anaemia induced by PRRSV was probably due to a direct or indirect effect on 
      erythroid precursor cells in the bone marrow.
FAU - Halbur, R G
AU  - Halbur RG
AD  - Iowa State University, College of Veterinary Medicine, Ames 50011, USA.
FAU - Pallares, F J
AU  - Pallares FJ
FAU - Rathje, J A
AU  - Rathje JA
FAU - Evans, R
AU  - Evans R
FAU - Hagemoser, W A
AU  - Hagemoser WA
FAU - Paul, P S
AU  - Paul PS
FAU - Meng, X J
AU  - Meng XJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Vet Rec
JT  - The Veterinary record
JID - 0031164
RN  - 0 (Hemoglobins)
SB  - IM
MH  - Anemia/*veterinary/virology
MH  - Animals
MH  - Blood Cell Count/veterinary
MH  - Erythroid Precursor Cells/*cytology/virology
MH  - Hematocrit/veterinary
MH  - Hemoglobins/analysis
MH  - Myeloid Cells/*cytology
MH  - Porcine Reproductive and Respiratory Syndrome/*blood/pathology
MH  - Porcine respiratory and reproductive syndrome virus/*pathogenicity
MH  - Random Allocation
MH  - Swine
MH  - Swine Diseases/blood/virology
MH  - Virulence
EDAT- 2002/10/10 04:00
MHDA- 2003/04/04 05:00
CRDT- 2002/10/10 04:00
PHST- 2002/10/10 04:00 [pubmed]
PHST- 2003/04/04 05:00 [medline]
PHST- 2002/10/10 04:00 [entrez]
AID - 10.1136/vr.151.12.344 [doi]
PST - ppublish
SO  - Vet Rec. 2002 Sep 21;151(12):344-8. doi: 10.1136/vr.151.12.344.