PMID- 12372563
OWN - NLM
STAT- MEDLINE
DCOM- 20021223
LR  - 20190719
IS  - 0361-9230 (Print)
IS  - 0361-9230 (Linking)
VI  - 58
IP  - 6
DP  - 2002 Sep 30
TI  - Protection of cultured oligodendrocytes against tumor necrosis factor-alpha by 
      the antioxidants coenzyme Q(10) and N-acetyl cysteine.
PG  - 587-92
AB  - Tumor necrosis factor-alpha (TNF-alpha) retards the rate of terminal maturation 
      of oligodendrocytes in vitro. The following respective compounds were used along 
      with TNF-alpha in order to try and restore the normal rate of maturation: (1). 
      the antioxidant, coenzyme Q(10) (CoQ(10)); (2). the antioxidant, N-acetyl 
      cysteine (NAC); (3). creatine, which helps to preserve cellular energy; and (4) 
      S-adenosyl methionine (SAM), which contributes to the biosynthesis of lipids and 
      proteins. Of these compounds, only CoQ(10) or NAC was able to restore the numbers 
      of mature myelin basic protein-positive cells and the ability of the 
      oligodendrocytes to form membrane sheets. If TNF-alpha treatment causes oxidative 
      damage by compromising oxidative metabolism in oligodendrocytes, increasing 
      products of lipid peroxidation and/or generating radical oxygen species that can 
      interfere with maturation signals, CoQ(10) and NAC may protect oligodendrocytes 
      by reversing one or more of those destructive processes during terminal 
      maturation.
FAU - Cammer, Wendy
AU  - Cammer W
AD  - Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, 
      USA. wcammer@aecom.yu.edu
LA  - eng
GR  - RG2971/RG/CSR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
RN  - 0 (Antioxidants)
RN  - 0 (Coenzymes)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 1339-63-5 (Ubiquinone)
RN  - EJ27X76M46 (coenzyme Q10)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
MH  - Acetylcysteine/*pharmacology
MH  - Animals
MH  - Animals, Newborn
MH  - Antioxidants/*pharmacology
MH  - Cells, Cultured
MH  - Coenzymes
MH  - Oligodendroglia/cytology/*drug effects/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Telencephalon/cytology/drug effects/metabolism
MH  - Tumor Necrosis Factor-alpha/*pharmacology
MH  - Ubiquinone/*analogs & derivatives/*pharmacology
EDAT- 2002/10/10 04:00
MHDA- 2002/12/27 04:00
CRDT- 2002/10/10 04:00
PHST- 2002/10/10 04:00 [pubmed]
PHST- 2002/12/27 04:00 [medline]
PHST- 2002/10/10 04:00 [entrez]
AID - S0361923002008304 [pii]
AID - 10.1016/s0361-9230(02)00830-4 [doi]
PST - ppublish
SO  - Brain Res Bull. 2002 Sep 30;58(6):587-92. doi: 10.1016/s0361-9230(02)00830-4.