PMID- 12375141
OWN - NLM
STAT- MEDLINE
DCOM- 20021213
LR  - 20071115
IS  - 0944-1174 (Print)
IS  - 0944-1174 (Linking)
VI  - 37
IP  - 9
DP  - 2002
TI  - Numerical chromosomal abnormality in gastric MALT lymphoma and diffuse large 
      B-cell lymphoma.
PG  - 691-6
AB  - BACKGROUND: We investigated numerical chromosomal abnormalities, using the 
      fluorescence in situ hybridization (FISH) method, in gastric mucosa-associated 
      lymphoid tissue (MALT) lymphoma and diffuse large B-cell lymphoma (DLBL). We also 
      compared the histopathological findings, including the presence or absence of 
      Helicobacter pylori infection, with the analytical results. METHODS: Sixteen 
      patients who underwent operation for malignant gastric lymphoma in our department 
      were divided into three groups: patients with low-grade gastric MALT lymphoma 
      (l-MALT; n = 5), those with high-grade gastric MALT lymphoma (h-MALT; n = 8), and 
      those with DLBL (n = 3). Numerical abnormalities of chromosomes 8, 9, 12, and 17 
      were investigated by the FISH method, and the presence or absence of H. pylori 
      infection was microscopically examined. RESULTS: Numerical abnormality was 
      observed in chromosome 12 in 11 patients (68.8%), in chromosome 8 in 10 (62.5%), 
      and in chromosome 17 in 5 (31.3%), showing a high frequency. H. pylori infection 
      was detected in 80% and 50% of patients with l-MALT and h-MALT, respectively, but 
      no H. pylori infection was observed in patients with DLBL. CONCLUSIONS: A new 
      biological characteristic of gastric MALT lymphoma was obtained, i.e., a high 
      frequency of numerical abnormalities of chromosomes 12, 8, and 17. There was no 
      correlation between the numerical chromosomal abnormalities and the 
      clinicopathological findings.
FAU - Watanobe, Ikuo
AU  - Watanobe I
AD  - Second Department of Surgery, Juntendo University, School of Medicine, 2-1-1 
      Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
FAU - Takamori, Shigeru
AU  - Takamori S
FAU - Kojima, Kuniaki
AU  - Kojima K
FAU - Fukasawa, Masaki
AU  - Fukasawa M
FAU - Beppu, Tomoe
AU  - Beppu T
FAU - Futagawa, Shunji
AU  - Futagawa S
FAU - Hirai, Shu
AU  - Hirai S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Japan
TA  - J Gastroenterol
JT  - Journal of gastroenterology
JID - 9430794
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 12/genetics
MH  - Chromosomes, Human, Pair 17/genetics
MH  - Chromosomes, Human, Pair 8/genetics
MH  - Chromosomes, Human, Pair 9/genetics
MH  - Female
MH  - Helicobacter Infections/genetics/microbiology/pathology
MH  - Helicobacter pylori/isolation & purification
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, B-Cell/*genetics/microbiology/*pathology
MH  - Lymphoma, B-Cell, Marginal Zone/*genetics/microbiology/*pathology
MH  - Lymphoma, Large B-Cell, Diffuse/*genetics/microbiology/*pathology
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Stomach Neoplasms/*genetics/microbiology/*pathology
EDAT- 2002/10/11 04:00
MHDA- 2002/12/17 04:00
CRDT- 2002/10/11 04:00
PHST- 2002/10/11 04:00 [pubmed]
PHST- 2002/12/17 04:00 [medline]
PHST- 2002/10/11 04:00 [entrez]
AID - 10.1007/s005350200113 [doi]
PST - ppublish
SO  - J Gastroenterol. 2002;37(9):691-6. doi: 10.1007/s005350200113.