PMID- 12375636
OWN - NLM
STAT- MEDLINE
DCOM- 20021024
LR  - 20041117
IS  - 0002-9173 (Print)
IS  - 0002-9173 (Linking)
VI  - 118
IP  - 4
DP  - 2002 Oct
TI  - Chromosome 1p allelic loss by fluorescence in situ hybridization is not observed 
      in dysembryoplastic neuroepithelial tumors.
PG  - 512-7
AB  - Differentiation of dysembryoplastic neuroepithelial tumor (DNT) from cystic 
      low-grade oligodendroglioma, particularly in a limited biopsy orfragmented 
      specimen, may be impossible. Research has shown that allelic loss of chromosome 
      1p is a relatively common finding in oligodendrogliomas. Little is known about 
      chromosome 1p status in DNT. We retrospectively evaluated 14 DNTs for loss of 
      heterozygosity (LOH) on chromosome 1p by fluorescence in situ hybridization 
      (FISH) and compared the results with 1p FISH analysis in 57 low-grade 
      oligodendrogliomas (World Health Organization grade II). The 14 DNTs arose in 8 
      females and 6 males (mean age, 20.9 years at the time of surgery). All 14 DNTs 
      were 1p intact by FISH analysis. The 57 low-grade oligodendrogliomas arose in 31 
      males and 26 females (mean age, 43.2 years). LOH on chromosome 1p was present in 
      31 (54%) of 57 tumors; the remaining 26 tumors were 1p intact. LOH on chromosome 
      1p is not a feature of DNTs. LOH on chromosome 1p may be a useful differential 
      diagnostic feature (favoring oligodendroglioma) in a subset of cases in which 
      specimen fragmentation or size raises the differential diagnosis of DNT vs 
      oligodendroglioma.
FAU - Prayson, Richard A
AU  - Prayson RA
AD  - Department of Neurological Surgery, Cleveland Clinic Foundation, OH 44195, USA.
FAU - Castilla, Elias A
AU  - Castilla EA
FAU - Hartke, Marybeth
AU  - Hartke M
FAU - Pettay, James
AU  - Pettay J
FAU - Tubbs, Raymond R
AU  - Tubbs RR
FAU - Barnett, Gene H
AU  - Barnett GH
LA  - eng
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain Neoplasms/*genetics/pathology
MH  - Child
MH  - *Chromosomes, Human, Pair 1
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Loss of Heterozygosity/*genetics
MH  - Male
MH  - Middle Aged
MH  - Neoplasms, Neuroepithelial/*genetics/pathology
MH  - Oligodendroglioma/genetics/pathology
MH  - Teratoma/*genetics/pathology
EDAT- 2002/10/12 04:00
MHDA- 2002/10/31 04:00
CRDT- 2002/10/12 04:00
PHST- 2002/10/12 04:00 [pubmed]
PHST- 2002/10/31 04:00 [medline]
PHST- 2002/10/12 04:00 [entrez]
AID - 10.1309/KLAG-TARW-WDBJ-5CTJ [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2002 Oct;118(4):512-7. doi: 10.1309/KLAG-TARW-WDBJ-5CTJ.