PMID- 12375740
OWN - NLM
STAT- MEDLINE
DCOM- 20030327
LR  - 20191106
IS  - 0892-3973 (Print)
IS  - 0892-3973 (Linking)
VI  - 24
IP  - 3
DP  - 2002 Aug
TI  - Anti-allergic effects of Sanguisorba officinalis on animal models of allergic 
      reactions.
PG  - 455-68
AB  - We investigated the effect of aqueous extract of Sanguisorba officinalis 
      L.(Rosaceae) root (SOAE) on the immediate-type allergic reactions in vivo and in 
      vitro. SOAE (0.01 to 1 g/kg) inhibited systemic allergic reaction induced by 
      compound 48/80. When SOAE was employed in a systemic allergic reaction test, the 
      plasma histamine levels were reduced in a dose-dependent manner. SOAE (0.001 to 1 
      g/kg) dose-dependently inhibited passive cutaneous anaphylaxis (PCA) activated by 
      anti-dinitrophenyl (DNP) IgE. SOAE (0.001 to 1 mg/mL) also dose-dependently 
      inhibited the histamine release from rat peritoneal mast cells (RPMC) activated 
      by compound 48/80 or anti-DNP IgE. The level of cyclic AMP (cAMP) in RPMC, When 
      SOAE was added, significantly increased compared with that of normal control. 
      Moreover, SOAE (0.01 to 1 mg/mL) had a significant inhibitory effect on anti-DNP 
      IgE-induced tumor necrosis factor-alpha (TNF-alpha) production. These results 
      suggest that SOAE may be beneficial in the regulation of immediate-type allergic 
      reaction.
FAU - Shin, Tae-Yong
AU  - Shin TY
AD  - College of Pharmacy, Woosuk University, Chonju, Chonbuk, South Korea.
FAU - Lee, Kyeong-Bo
AU  - Lee KB
FAU - Kim, Sang-Hyun
AU  - Kim SH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Immunopharmacol Immunotoxicol
JT  - Immunopharmacology and immunotoxicology
JID - 8800150
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
SB  - IM
MH  - Animals
MH  - Histamine Release/drug effects
MH  - Hypersensitivity/*drug therapy
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - *Phytotherapy
MH  - Plant Extracts/*therapeutic use
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Sanguisorba
MH  - Tumor Necrosis Factor-alpha/biosynthesis
MH  - p-Methoxy-N-methylphenethylamine/pharmacology
EDAT- 2002/10/12 04:00
MHDA- 2003/03/28 05:00
CRDT- 2002/10/12 04:00
PHST- 2002/10/12 04:00 [pubmed]
PHST- 2003/03/28 05:00 [medline]
PHST- 2002/10/12 04:00 [entrez]
AID - 10.1081/iph-120014729 [doi]
PST - ppublish
SO  - Immunopharmacol Immunotoxicol. 2002 Aug;24(3):455-68. doi: 10.1081/iph-120014729.