PMID- 12376155
OWN - NLM
STAT- MEDLINE
DCOM- 20030321
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 74
IP  - 1
DP  - 2002 Dec
TI  - Locomotor stimulant effects of nornicotine: role of dopamine.
PG  - 87-94
AB  - Nornicotine (NORNIC) is a tobacco alkaloid and behaviorally active nicotine 
      metabolite in vivo. Previous behavioral research has shown that NORNIC has 
      locomotor stimulant and reinforcing effects in rats similar to that of nicotine. 
      Results from the current study showed that a bilateral lesion of the nucleus 
      accumbens decreased the locomotor stimulant effect of NORNIC across repeated 
      injections. Pretreatment with the dopamine (DA) D1 receptor antagonist SCH23390 
      did not block the locomotor stimulant effect of NORNIC or the initiation of 
      sensitization following repeated NORNIC administration. The D2 receptor 
      antagonist eticlopride, however, blocked both the stimulant effect and the 
      initiation of sensitization following repeated NORNIC. Additionally, NORNIC was 
      found to increase synthesis and metabolism of DA, with a greater effect in the 
      mesolimbic pathway compared to the nigrostriatal pathway. Taken together, these 
      results suggest that expression of NORNIC-induced locomotor activity is dependent 
      upon ascending dopaminergic mesolimbic projections, providing additional evidence 
      that NORNIC plays a contributory role in tobacco dependence.
FAU - Green, T A
AU  - Green TA
AD  - Department of Psychology, University of Kentucky, Lexington, KY 40506-0044, USA.
FAU - Brown, R W
AU  - Brown RW
FAU - Phillips, S B
AU  - Phillips SB
FAU - Dwoskin, L P
AU  - Dwoskin LP
FAU - Bardo, M T
AU  - Bardo MT
LA  - eng
GR  - DA00399/DA/NIDA NIH HHS/United States
GR  - DA08656/DA/NIDA NIH HHS/United States
GR  - F31 DA06093/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Benzazepines)
RN  - 0 (Dopamine Antagonists)
RN  - 0 (Salicylamides)
RN  - 0 (Sympatholytics)
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 63-84-3 (Dihydroxyphenylalanine)
RN  - 6M3C89ZY6R (Nicotine)
RN  - 83H6L5QD8Z (nornicotine)
RN  - 8HW4YBZ748 (Oxidopamine)
RN  - J8M468HBH4 (eticlopride)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/metabolism
MH  - Animals
MH  - Benzazepines/pharmacology
MH  - Dihydroxyphenylalanine/metabolism
MH  - Dopamine/*physiology
MH  - Dopamine Antagonists/pharmacology
MH  - Drug Synergism
MH  - Male
MH  - Motor Activity/*drug effects
MH  - Nicotine/*analogs & derivatives/*pharmacology
MH  - Nucleus Accumbens/drug effects
MH  - Oxidopamine
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Salicylamides/pharmacology
MH  - Stimulation, Chemical
MH  - Sympathectomy, Chemical
MH  - Sympatholytics
EDAT- 2002/10/12 04:00
MHDA- 2003/03/22 04:00
CRDT- 2002/10/12 04:00
PHST- 2002/10/12 04:00 [pubmed]
PHST- 2003/03/22 04:00 [medline]
PHST- 2002/10/12 04:00 [entrez]
AID - S0091305702009607 [pii]
AID - 10.1016/s0091-3057(02)00960-7 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2002 Dec;74(1):87-94. doi: 
      10.1016/s0091-3057(02)00960-7.