PMID- 12376159
OWN - NLM
STAT- MEDLINE
DCOM- 20030321
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 74
IP  - 1
DP  - 2002 Dec
TI  - The nucleus accumbens as a site of action for rewarding properties of 
      testosterone and its 5alpha-reduced metabolites.
PG  - 119-27
AB  - Testosterone (T)'s positive hedonic effects may be mediated by actions of its 
      metabolites, dihydrotestosterone (DHT) or 3alpha-androstanediol (3alpha-diol), in 
      the nucleus accumbens (NA). In Experiment 1, adult, intact, male rats were 
      systemically administered 1 mg of T, DHT, 3alpha-diol or vehicle, at different 
      time points to examine concentrations of androgens in the NA. Rats administered 
      3alpha-diol had significantly increased concentrations of 3alpha-diol in the 
      region of the brain encompassing the NA. These data are consistent with previous 
      data from our laboratory demonstrating that 3alpha-diol elicits a conditioned 
      place preference (CPP) more effectively than either T or DHT, when administered 
      systemically. In Experiment 2, rats received implants of T, DHT or 3alpha-diol to 
      the NA immediately prior to placement in the CPP apparatus on conditioning days. 
      Implants of T, DHT or 3alpha-diol, but not vehicle, significantly increased time 
      spent on the non-preferred side of the chamber on the test day. This effect was 
      only produced by androgenic stimulation of the shell of the NA and not the core 
      of the NA. Thus, androgen regimens we have previously found to enhance CPP 
      produced the greatest increases in 3alpha-diol concentrations in the NA region 
      and direct implants of T, DHT or 3alpha-diol to the shell, but not the core, of 
      the NA enhanced CPP. These data are consistent with the hypothesis that the 
      hedonic effects of T may be due to actions of its metabolites in the NA.
FAU - Frye, C A
AU  - Frye CA
AD  - Department of Psychology, The University at Albany-SUNY, Albany, NY 12222, USA. 
      cafrye@cnsunix.albany.edu
FAU - Rhodes, M E
AU  - Rhodes ME
FAU - Rosellini, R
AU  - Rosellini R
FAU - Svare, B
AU  - Svare B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Drug Implants)
RN  - 08J2K08A3Y (Dihydrotestosterone)
RN  - 25126-76-5 (Androstane-3,17-diol)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Androstane-3,17-diol/administration & dosage/pharmacokinetics/*pharmacology
MH  - Animals
MH  - Conditioning, Operant/drug effects
MH  - Dihydrotestosterone/administration & dosage/pharmacokinetics/*pharmacology
MH  - Drug Implants
MH  - Male
MH  - Motor Activity/drug effects
MH  - Nucleus Accumbens/metabolism/*physiology
MH  - Rats
MH  - *Reward
MH  - Testosterone/administration & dosage/pharmacokinetics/*pharmacology
EDAT- 2002/10/12 04:00
MHDA- 2003/03/22 04:00
CRDT- 2002/10/12 04:00
PHST- 2002/10/12 04:00 [pubmed]
PHST- 2003/03/22 04:00 [medline]
PHST- 2002/10/12 04:00 [entrez]
AID - S0091305702009681 [pii]
AID - 10.1016/s0091-3057(02)00968-1 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2002 Dec;74(1):119-27. doi: 
      10.1016/s0091-3057(02)00968-1.