PMID- 12376180
OWN - NLM
STAT- MEDLINE
DCOM- 20030107
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 952
IP  - 2
DP  - 2002 Oct 18
TI  - Urocortin shares the memory modulating effects of corticotropin-releasing factor 
      (CRF): mediation by CRF1 receptors.
PG  - 200-10
AB  - Intracerebroventricular (i.c.v.) administration of corticotropin-releasing factor 
      (CRF) biphasically affects performance in tests of learning and memory. In the 
      present study, we used CRF, urocortin (Ucn), a recently cloned CRF homologue, and 
      CRF receptor antagonists, to determine which CRF receptor subtype(s) mediate the 
      memory modulating effects of CRF receptor agonists in male Wistar rats. Under 
      difficult learning conditions (massed trials), i.c.v. pretreatment with CRF or 
      Ucn facilitated the acquisition of spatial navigation in the Morris water maze in 
      a non-dose-dependent fashion (optimal doses of 0.1 and 0.03 microg, 
      respectively). Under less difficult learning conditions (spaced trials), both 
      peptides impaired water maze performance. In addition, with i.c.v. posttraining 
      treatment, the peptides were equipotent (1.0 microg) in facilitating the 
      consolidation of passive avoidance learning. The performance-enhancing effects of 
      Ucn in both water maze and passive avoidance paradigms were reversed by i.c.v. 
      pretreatment with D-Phe CRF(12-41) (2.5, 5 microg), a broad CRF(1)/CRF(2) 
      receptor antagonist, or antalarmin (10 microg), a potent, nonpeptide, CRF(1) 
      selective receptor antagonist. Thus, Ucn shares CRF's memory-modulating effects, 
      and these effects appear to be mediated via the CRF(1) receptor. These findings 
      are consistent with the hypothesis that CRF receptor agonists affect performance 
      in tests of learning and memory by increasing arousal.
FAU - Zorrilla, Eric P
AU  - Zorrilla EP
AD  - Neurocrine Biosciences, Inc., La Jolla, CA, USA. ezorrilla@scripps.edu
FAU - Schulteis, Gery
AU  - Schulteis G
FAU - Ormsby, Amanda
AU  - Ormsby A
FAU - Klaassen, Alwin
AU  - Klaassen A
FAU - Ling, Nicholas
AU  - Ling N
FAU - McCarthy, James R
AU  - McCarthy JR
FAU - Koob, George F
AU  - Koob GF
FAU - De Souza, Errol B
AU  - De Souza EB
LA  - eng
GR  - 2R44-NS33426/NS/NINDS NIH HHS/United States
GR  - 2R44-NS33489/NS/NINDS NIH HHS/United States
GR  - 5T32-MH19185-07/MH/NIMH NIH HHS/United States
GR  - NIDDK 26741/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Receptors, Corticotropin-Releasing Hormone)
RN  - 0 (Urocortins)
RN  - 5CLY6W2H1M (CRF receptor type 1)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
SB  - IM
MH  - Animals
MH  - Avoidance Learning/drug effects/physiology
MH  - Corticotropin-Releasing Hormone/*pharmacology/physiology
MH  - Dose-Response Relationship, Drug
MH  - Injections, Intraventricular
MH  - Male
MH  - Memory/*drug effects/physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Reaction Time/drug effects/physiology
MH  - Receptors, Corticotropin-Releasing Hormone/*agonists/antagonists & 
      inhibitors/*physiology
MH  - Urocortins
EDAT- 2002/10/12 04:00
MHDA- 2003/01/08 04:00
CRDT- 2002/10/12 04:00
PHST- 2002/10/12 04:00 [pubmed]
PHST- 2003/01/08 04:00 [medline]
PHST- 2002/10/12 04:00 [entrez]
AID - S0006899302033450 [pii]
AID - 10.1016/s0006-8993(02)03345-0 [doi]
PST - ppublish
SO  - Brain Res. 2002 Oct 18;952(2):200-10. doi: 10.1016/s0006-8993(02)03345-0.