PMID- 12376743
OWN - NLM
STAT- MEDLINE
DCOM- 20021209
LR  - 20111117
IS  - 1434-5161 (Print)
IS  - 1434-5161 (Linking)
VI  - 47
IP  - 10
DP  - 2002
TI  - Single-nucleotide polymorphisms in the class II region of the major 
      histocompatibility complex in Japanese patients with immunoglobulin A 
      nephropathy.
PG  - 532-8
AB  - Immunoglobulin A nephropathy (IgAN) is a form of chronic glomerulonephritis of 
      unknown etiology and pathogenesis. Immunogenetic studies have not conclusively 
      indicated that human leukocyte antigen (HLA) is involved. As a first step in 
      investigating a possible relationship between HLA class II genes and IgAN, we 
      analyzed the extent of linkage disequilibrium (LD) in this region of chromosome 
      6p21.3 in a Japanese test population and found extended LD blocks within the 
      class II locus. We designed a case-control association study of single-nucleotide 
      polymorphisms (SNPs) in each of those LD blocks, and determined that SNPs located 
      in the HLA- DRA gene were significantly associated with an increased risk of IgAN 
      ( P = 0.000001, odds ratio = 1.91 [95% confidence interval 1.46-2.49]); SNPs in 
      other LD blocks were not. Our data imply that some haplotype of the HLA- DRA 
      locus has an important role in the development of IgAN in Japanese patients.
FAU - Akiyama, Fumihiro
AU  - Akiyama F
AD  - Human Genome Center, The Institute of Medical Science, University of Tokyo, 
      Japan.
FAU - Tanaka, Toshihiro
AU  - Tanaka T
FAU - Yamada, Ryo
AU  - Yamada R
FAU - Ohnishi, Yozo
AU  - Ohnishi Y
FAU - Tsunoda, Tatsuhiko
AU  - Tsunoda T
FAU - Maeda, Shiro
AU  - Maeda S
FAU - Takei, Takashi
AU  - Takei T
FAU - Obara, Wataru
AU  - Obara W
FAU - Ito, Kyoko
AU  - Ito K
FAU - Honda, Kazuho
AU  - Honda K
FAU - Uchida, Keiko
AU  - Uchida K
FAU - Tsuchiya, Ken
AU  - Tsuchiya K
FAU - Nitta, Kosaku
AU  - Nitta K
FAU - Yumura, Wako
AU  - Yumura W
FAU - Nihei, Hiroshi
AU  - Nihei H
FAU - Ujiie, Takashi
AU  - Ujiie T
FAU - Nagane, Yutaka
AU  - Nagane Y
FAU - Miyano, Satoru
AU  - Miyano S
FAU - Suzuki, Yasushi
AU  - Suzuki Y
FAU - Fujioka, Tomoaki
AU  - Fujioka T
FAU - Narita, Ichiei
AU  - Narita I
FAU - Gejyo, Fumitake
AU  - Gejyo F
FAU - Nakamura, Yusuke
AU  - Nakamura Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Hum Genet
JT  - Journal of human genetics
JID - 9808008
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR alpha-Chains)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Case-Control Studies
MH  - Chromosomes, Human, Pair 6/genetics
MH  - Female
MH  - Genes, MHC Class II/*genetics
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Glomerulonephritis, IGA/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DR alpha-Chains
MH  - Humans
MH  - Japan
MH  - Linkage Disequilibrium/genetics
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide/*genetics
EDAT- 2002/10/12 04:00
MHDA- 2002/12/10 04:00
CRDT- 2002/10/12 04:00
PHST- 2002/10/12 04:00 [pubmed]
PHST- 2002/12/10 04:00 [medline]
PHST- 2002/10/12 04:00 [entrez]
AID - 10.1007/s100380200080 [doi]
PST - ppublish
SO  - J Hum Genet. 2002;47(10):532-8. doi: 10.1007/s100380200080.