PMID- 12376744
OWN - NLM
STAT- MEDLINE
DCOM- 20021209
LR  - 20081121
IS  - 1434-5161 (Print)
IS  - 1434-5161 (Linking)
VI  - 47
IP  - 10
DP  - 2002
TI  - No intraindividual variation of disomy rate in sperm samples.
PG  - 539-42
AB  - We assessed possible inter- and intraindividual variations in the frequency of 
      disomy in sperm cells from three men with abnormal sperm analysis parameters. 
      Mono- and dual-color fluorescence in situ hybridization (FISH) was applied to 
      sperm cells from different samples of the men. Four men with a normal sperm 
      profile were used as controls. The samples were taken separately over a period of 
      6 months. FISH probes used for the disomy rate analysis were clones from the 
      satellite region of chromosomes 8, 18, X, and Y. The study group showed a 
      significantly higher disomy rate compared with the control group, whereas there 
      was no significant difference in the disomy rate between three different samples 
      from the same individuals. These results suggest that the sampling time has no 
      importance in assessing the rate of nondisjunction in sperm cells.
FAU - Amiel, Aliza
AU  - Amiel A
AD  - Genetic Institute, Meir Hospital, Kfar-Saba 44281, Israel. alizaamiel@hotmail.com
FAU - Bartoov, Benjamin
AU  - Bartoov B
FAU - Pevsner, Dina
AU  - Pevsner D
FAU - Sardos-Albertini, Federika
AU  - Sardos-Albertini F
FAU - Fejgin, Moshe D
AU  - Fejgin MD
LA  - eng
PT  - Case Reports
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - J Hum Genet
JT  - Journal of human genetics
JID - 9808008
SB  - IM
MH  - Adult
MH  - *Aneuploidy
MH  - Case-Control Studies
MH  - Chromosomes, Human, Pair 18/genetics
MH  - Chromosomes, Human, Pair 8/genetics
MH  - *Diploidy
MH  - *Genetic Variation
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Infertility, Male
MH  - Karyotyping
MH  - Male
MH  - Middle Aged
MH  - Sex Chromosome Aberrations
MH  - *Sperm Count
MH  - Spermatozoa/*physiology
MH  - X Chromosome/genetics
MH  - Y Chromosome/genetics
EDAT- 2002/10/12 04:00
MHDA- 2002/12/10 04:00
CRDT- 2002/10/12 04:00
PHST- 2002/10/12 04:00 [pubmed]
PHST- 2002/12/10 04:00 [medline]
PHST- 2002/10/12 04:00 [entrez]
AID - 10.1007/s100380200081 [doi]
PST - ppublish
SO  - J Hum Genet. 2002;47(10):539-42. doi: 10.1007/s100380200081.