PMID- 12376852
OWN - NLM
STAT- MEDLINE
DCOM- 20030321
LR  - 20061115
IS  - 0941-293X (Print)
IS  - 0941-293X (Linking)
VI  - 99
IP  - 10
DP  - 2002 Oct
TI  - [Quantitative and objective topometrical analysis of drusen of the optic nerve 
      head with the Heidelberg retina tomograph (HRT)].
PG  - 768-73
AB  - BACKGROUND AND PURPOSE: Optic nerve head drusen (ONHD) are one of the most 
      frequent causes for congenital swelling of the optic nerve head. Visual field and 
      retinal nerve fiber layer defects are reported in cases of ONHD. The Heidelberg 
      Retina Tomograph (HRT) allows a 3-dimensional topometric analysis of the optic 
      nerve disc and measurement of the peripapillary mean retinal nerve fiber layer. 
      PATIENTS AND METHODS: A total of 18 eyes from 9 patients with sonographically 
      confirmed drusen were analyzed with the HRT. Data were compared to a control 
      group of 18 eyes from 9 matched healthy individuals. Statistical analyses were 
      performed by using ANOVA (univariate). All patients with ONHD underwent a 
      computerised visual field test (30 degrees, Octopus 101). Due to a bad 
      reliability factor of over 10 in the visual fields by 4 out of 18 eyes, only 
      measurements from 14 eyes were included in the study. We correlated visual field 
      and HRT parameters and calculated the Pearson's correlation coefficient (r). 
      RESULTS: We found a significant difference in the measured parameter mean retinal 
      nerve fiber layer (RNFL) thickness ( p<0.05) between the two groups. In the ONHD 
      group a negative correlation coefficient was found between the peripapillary mean 
      RNFL thickness and the loss variance (r=-0.50, p=0.03) as well as between the 
      peripapillary RNFL cross-sectional area and the loss variance (r=-0.47, p=0.04). 
      CONCLUSIONS: The HRT is able to detect a peripapillary RNFL thinning in cases 
      with ONHD. The mean RNFL thickness correlated with the loss variance. The HRT 
      should be used to perform a quantitative and objective topometric analysis in 
      cases with ONHD.
FAU - Kuchenbecker, J
AU  - Kuchenbecker J
AD  - Augenklinik der Otto-von-Guericke Universitat Magdeburg, Germany. 
      mail@jkuchenbecker.de
FAU - Wecke, T
AU  - Wecke T
FAU - Vorwerk, C K
AU  - Vorwerk CK
FAU - Behrens-Baumann, W
AU  - Behrens-Baumann W
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Quantitative und objektive topo-metrische Analyse von Drusenpapillen mit dem 
      Heidelberg-Retina-Tomographen (HRT).
PL  - Germany
TA  - Ophthalmologe
JT  - Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
JID - 9206148
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - *Image Processing, Computer-Assisted
MH  - Imaging, Three-Dimensional
MH  - Male
MH  - *Microscopy, Confocal
MH  - Middle Aged
MH  - Nerve Fibers/pathology
MH  - *Ophthalmoscopy
MH  - Optic Disk/*pathology
MH  - Optic Disk Drusen/*diagnosis
MH  - Retina/pathology
MH  - Sensitivity and Specificity
MH  - *Tomography
EDAT- 2002/10/12 04:00
MHDA- 2003/03/22 04:00
CRDT- 2002/10/12 04:00
PHST- 2002/10/12 04:00 [pubmed]
PHST- 2003/03/22 04:00 [medline]
PHST- 2002/10/12 04:00 [entrez]
AID - 10.1007/s00347-002-0639-4 [doi]
PST - ppublish
SO  - Ophthalmologe. 2002 Oct;99(10):768-73. doi: 10.1007/s00347-002-0639-4.