PMID- 12377410
OWN - NLM
STAT- MEDLINE
DCOM- 20021105
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 137
IP  - 1
DP  - 2002 Aug
TI  - A novel t(16;20)(q22;p13) in polycythemia vera.
PG  - 29-32
AB  - We report a patient with polycythemia vera whose bone marrow cells carried a 
      novel t(16;20)(q22;p13) as detected by karyotype analysis using G- and Q-banding 
      techniques. The reciprocal translocation was confirmed by fluorescence in situ 
      hybridization (FISH) using DNA libraries of chromosomes 16 and 20. To our 
      knowledge, t(16;20)(q22;p13) has not been reported previously. The core binding 
      factor beta (CBFbeta) gene located on 16q22 is known to be frequently involved in 
      acute myelocytic leukemia. On the other hand, the 20p13 locus contains a gene 
      encoding protein kinase CK2alpha, which is closely related to cell proliferation 
      and cell cycle regulation. The t(16;20)(q22;p13) may be one of the cytogenetic 
      aberrations in myeloproliferative disorders, and therefore, our observation 
      warrants further studies on a possible involvement of the genes resulting from 
      this translocation.
FAU - Daibata, Masanori
AU  - Daibata M
AD  - Department of Medicine, Kochi Medical School, 783-8505, Kochi, Japan. 
      daibatam@kochi-ms.ac.jp
FAU - Taguchi, Takahiro
AU  - Taguchi T
FAU - Taguchi, Hirokuni
AU  - Taguchi H
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Bone Marrow Cells/pathology
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 16
MH  - *Chromosomes, Human, Pair 20
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Middle Aged
MH  - Polycythemia Vera/*genetics/pathology
MH  - *Translocation, Genetic
EDAT- 2002/10/16 04:00
MHDA- 2002/11/26 04:00
CRDT- 2002/10/16 04:00
PHST- 2002/10/16 04:00 [pubmed]
PHST- 2002/11/26 04:00 [medline]
PHST- 2002/10/16 04:00 [entrez]
AID - S0165460802005435 [pii]
AID - 10.1016/s0165-4608(02)00543-5 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2002 Aug;137(1):29-32. doi: 
      10.1016/s0165-4608(02)00543-5.