PMID- 12377414
OWN - NLM
STAT- MEDLINE
DCOM- 20021105
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 137
IP  - 1
DP  - 2002 Aug
TI  - Rearrangements involving the 13q chromosome arm committed to the progression of 
      laryngeal squamous cell carcinoma.
PG  - 54-8
AB  - Our recent comparative genomic hybridization (CGH) study has shown that losses of 
      the long arm of chromosome 13 were the most common aberrations in primary larynx 
      tumors and their corresponding metastases. In the present study, 20 pairs of 
      primary larynx tumors and their metastases were analyzed by interphase 
      fluorescence in situ hybridization (FISH) with three different 13q-specific 
      probes (RB1, D13S25, and 13qtel). Our experiments were generally consistent with 
      the CGH results, with some differences indicating cell population heterogeneity 
      in the analyzed cohort of tumors. The results provided further evidence for the 
      putative role of the RB1 gene alterations in the metastatic process, although a 
      contribution by other gene(s) during metastasis cannot be ruled out.
FAU - Kujawski, Maciej
AU  - Kujawski M
AD  - Institute of Human Genetics, Polish Academy of Sciences, Strzeszynska 32, Poznan, 
      Poland. kujma@man.poznan.pl
FAU - Rydzanicz, Malgorzata
AU  - Rydzanicz M
FAU - Sarlomo-Rikala, Maarit
AU  - Sarlomo-Rikala M
FAU - Szyfter, Krzysztof
AU  - Szyfter K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Genetic Markers)
RN  - 0 (Retinoblastoma Protein)
SB  - IM
MH  - Carcinoma, Squamous Cell/*genetics/pathology
MH  - Chromosome Deletion
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 13
MH  - Disease Progression
MH  - *Gene Rearrangement
MH  - Genetic Markers
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Laryngeal Neoplasms/*genetics/pathology
MH  - Loss of Heterozygosity
MH  - Neoplasm Metastasis/genetics
MH  - Retinoblastoma Protein/*genetics
EDAT- 2002/10/16 04:00
MHDA- 2002/11/26 04:00
CRDT- 2002/10/16 04:00
PHST- 2002/10/16 04:00 [pubmed]
PHST- 2002/11/26 04:00 [medline]
PHST- 2002/10/16 04:00 [entrez]
AID - S0165460802005459 [pii]
AID - 10.1016/s0165-4608(02)00545-9 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2002 Aug;137(1):54-8. doi: 10.1016/s0165-4608(02)00545-9.