PMID- 12378122
OWN - NLM
STAT- MEDLINE
DCOM- 20021125
LR  - 20171101
IS  - 0302-282X (Print)
IS  - 0302-282X (Linking)
VI  - 46
IP  - 2
DP  - 2002
TI  - Weight gain and serum leptin levels in patients on lithium treatment.
PG  - 67-9
AB  - Weight gain is a frequent adverse effect associated with lithium use. Leptin is 
      an adipocyte hormone, regulating food intake and energy balance providing the 
      hypothalamus with information on the amount of body fat. Therefore, we planned to 
      evaluate whether lithium administration was associated with weight gain, and 
      leptin levels. The study consisted of 15 consecutive inpatients with bipolar I 
      disorder according to DSM-III-R. The fasting serum leptin levels were measured. 
      The patients were evaluated at baseline and at the eighth week according to the 
      body mass index, weight, Young Mania Rating (YMRS) and Hamilton Depression Rating 
      (HAM-D) scales, and serum leptin levels. With respect to the leptin levels, a 
      significant difference was observed after lithium treatment. There was a 
      significant positive correlation between the changes in leptin levels and the 
      duration of illness. The change in total YMRS scores correlated with change in 
      leptin levels and that in weight. In conclusion, our result suggest that leptin 
      may be associated with lithium-induced weight gain.
CI  - Copyright 2002 S. Karger AG, Basel
FAU - Atmaca, Murad
AU  - Atmaca M
AD  - Department of Psychiatry, Firat University, School of Medicine, Elazig, Turkey. 
      matmaca_p@yahoo.com
FAU - Kuloglu, Murat
AU  - Kuloglu M
FAU - Tezcan, Ertan
AU  - Tezcan E
FAU - Ustundag, Bilal
AU  - Ustundag B
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - Switzerland
TA  - Neuropsychobiology
JT  - Neuropsychobiology
JID - 7512895
RN  - 0 (Leptin)
RN  - 9FN79X2M3F (Lithium)
SB  - IM
MH  - Adult
MH  - Bipolar Disorder/complications/drug therapy/psychology
MH  - Body Mass Index
MH  - Diet
MH  - Female
MH  - Humans
MH  - Leptin/*blood
MH  - Lithium/*adverse effects/therapeutic use
MH  - Male
MH  - Psychiatric Status Rating Scales
MH  - Weight Gain/*drug effects
EDAT- 2002/10/16 04:00
MHDA- 2002/11/26 04:00
CRDT- 2002/10/16 04:00
PHST- 2002/10/16 04:00 [pubmed]
PHST- 2002/11/26 04:00 [medline]
PHST- 2002/10/16 04:00 [entrez]
AID - 65414 [pii]
AID - 10.1159/000065414 [doi]
PST - ppublish
SO  - Neuropsychobiology. 2002;46(2):67-9. doi: 10.1159/000065414.