PMID- 12378520
OWN - NLM
STAT- MEDLINE
DCOM- 20021203
LR  - 20190722
IS  - 0046-8177 (Print)
IS  - 0046-8177 (Linking)
VI  - 33
IP  - 9
DP  - 2002 Sep
TI  - Perineural invasion in adenoid cystic carcinoma: Its causation/promotion by 
      brain-derived neurotrophic factor.
PG  - 933-6
AB  - Adenoid cystic carcinoma (ACC) is a common salivary gland neoplasm with a lengthy 
      clinical course and often late local recurrences after surgical resection. This 
      is accounted for histologically by its infiltrative capacity and distinct 
      propensity for perineural invasion. The expression of biological markers may help 
      explain the clinicopathologic course in ACCs. Brain-derived neurotrophic factor 
      (BDNF) is a growth factor known to be involved in neurogenesis. The aim of this 
      study is to elucidate the expression of BDNF in ACCs, which is currently unknown. 
      Twenty-nine cases of primary ACCs of the head and neck were immunostained to 
      analyze BDNF protein expression. Staining intensity was described as focal or 
      diffuse and graded on a 3-tiered scale. The study group comprised 20 adult 
      females (age 30 to 78) and 9 adult males (age 22 to 70). Sites of involvement 
      included the parotid gland (6 cases), nasopharynx (5), maxilla (4), palate (3), 
      trachea (3), submandibular gland (2), buccal mucosa (2), mandible (1), tongue 
      (1), lacrimal gland (1), and temporal region (1). All tumors exhibited diffuse 
      cytoplasmic staining; 11 cases were classified as 1+ intensity, 12 cases as 2+, 
      and six cases as 3+. Based on the results presented here, BDNF is unformly 
      expressed by ACC and may play a causative role in its predilection for perineural 
      invasion. ACCs may display neurogenesis with high levels of BDNF expression in 
      some tumors. Further studies are warranted to gain better understanding of this 
      possible relationship.
CI  - Copyright 2002, Elsevier Science (USA). All rights reserved.
FAU - Kowalski, Paul J
AU  - Kowalski PJ
AD  - University of Michigan Hospitals, Ann Arbor 48109, USA.
FAU - Paulino, Augusto F G
AU  - Paulino AF
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hum Pathol
JT  - Human pathology
JID - 9421547
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Carcinoma, Adenoid Cystic/*metabolism/pathology
MH  - Female
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Peripheral Nerves/*metabolism/pathology
MH  - Salivary Gland Neoplasms/*metabolism/pathology
EDAT- 2002/10/16 04:00
MHDA- 2002/12/04 04:00
CRDT- 2002/10/16 04:00
PHST- 2002/10/16 04:00 [pubmed]
PHST- 2002/12/04 04:00 [medline]
PHST- 2002/10/16 04:00 [entrez]
AID - S0046817702001259 [pii]
AID - 10.1053/hupa.2002.128249 [doi]
PST - ppublish
SO  - Hum Pathol. 2002 Sep;33(9):933-6. doi: 10.1053/hupa.2002.128249.