PMID- 12379530
OWN - NLM
STAT- MEDLINE
DCOM- 20021203
LR  - 20220227
IS  - 0003-4967 (Print)
IS  - 1468-2060 (Electronic)
IS  - 0003-4967 (Linking)
VI  - 61
IP  - 11
DP  - 2002 Nov
TI  - Modulation of cell recruitment by anti-inflammatory agents in antigen-induced 
      arthritis.
PG  - 1027-30
AB  - OBJECTIVE: To study the effect of meloxicam (MXC) and diclofenac (DCF) on the 
      recruitment of leucocytes during acute experimental arthritis. METHODS: Rabbits 
      with antigen-induced arthritis were treated with MXC, DCF, or not treated. After 
      48 hours, synovial fluid (SF) leucocyte influx and prostaglandin E(2) (PGE(2)) 
      levels were evaluated. Interleukin 8 (IL8) and monocyte chemotactic peptide-1 
      (MCP-1) expression and synthesis were studied in the inflamed tissues. RESULTS: 
      Arthritic knees showed synovial effusion with a high leucocyte count and PGE(2) 
      concentration, and an increased expression of IL8 and MCP-1. Both non-steroidal 
      anti-inflammatory drugs (NSAIDs) reduced PGE(2) levels and the polymorphonuclear 
      cell (PMN) concentration in SF, while the mononuclear cell (MN) concentration was 
      unchanged in the treated groups in comparison with controls. A definite reduction 
      of IL8 levels was obtained with the treatments, but the drugs did not prevent the 
      up regulation of MCP-1. CONCLUSION: The effect of these NSAIDs in acute arthritis 
      may be related to the down regulation of IL8 production. The results suggest a 
      differential effect of anti-inflammatory drugs on PMN and MN recruitment to the 
      joint.
FAU - Lopez-Armada, M J
AU  - Lopez-Armada MJ
AD  - Inflammation Research Unit, Fundacion Jimenez Diaz, Universidad Autonoma, Madrid, 
      Spain.
FAU - Sanchez-Pernaute, O
AU  - Sanchez-Pernaute O
FAU - Largo, R
AU  - Largo R
FAU - Diez-Ortego, I
AU  - Diez-Ortego I
FAU - Palacios, I
AU  - Palacios I
FAU - Egido, J
AU  - Egido J
FAU - Herrero-Beaumont, G
AU  - Herrero-Beaumont G
LA  - eng
PT  - Journal Article
PL  - England
TA  - Ann Rheum Dis
JT  - Annals of the rheumatic diseases
JID - 0372355
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cyclooxygenase Inhibitors)
RN  - 0 (Interleukin-8)
RN  - 0 (Thiazines)
RN  - 0 (Thiazoles)
RN  - 144O8QL0L1 (Diclofenac)
RN  - 9006-59-1 (Ovalbumin)
RN  - K7Q1JQR04M (Dinoprostone)
RN  - VG2QF83CGL (Meloxicam)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use
MH  - Arthritis, Experimental/*drug therapy/immunology
MH  - Chemokine CCL2/genetics/metabolism
MH  - Cyclooxygenase Inhibitors/therapeutic use
MH  - Diclofenac/*therapeutic use
MH  - Dinoprostone/biosynthesis
MH  - Gene Expression Regulation/drug effects
MH  - Interleukin-8/genetics/metabolism
MH  - Leukocytes/*drug effects/immunology
MH  - Meloxicam
MH  - Neutrophil Infiltration/drug effects
MH  - Ovalbumin
MH  - Rabbits
MH  - Thiazines/*therapeutic use
MH  - Thiazoles/*therapeutic use
PMC - PMC1753940
EDAT- 2002/10/16 04:00
MHDA- 2002/12/04 04:00
PMCR- 2005/11/01
CRDT- 2002/10/16 04:00
PHST- 2002/10/16 04:00 [pubmed]
PHST- 2002/12/04 04:00 [medline]
PHST- 2002/10/16 04:00 [entrez]
PHST- 2005/11/01 00:00 [pmc-release]
AID - 10.1136/ard.61.11.1027 [doi]
PST - ppublish
SO  - Ann Rheum Dis. 2002 Nov;61(11):1027-30. doi: 10.1136/ard.61.11.1027.