PMID- 12379547
OWN - NLM
STAT- MEDLINE
DCOM- 20030509
LR  - 20061115
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 166
IP  - 8
DP  - 2002 Oct 15
TI  - Alteration of balance between myeloid dendritic cells and plasmacytoid dendritic 
      cells in peripheral blood of patients with asthma.
PG  - 1050-4
AB  - Asthma, a well-known helper T cell Type 2 (Th2)-mediated disease, has a polarized 
      immune response toward a Th2 phenotype. However, the factors causing the Th2 
      polarization remain to be fully determined in this disease. Dendritic cells (DCs) 
      are the most potent antigen-presenting cells that play a central role in 
      initiating the primary immune response. In human blood, two functional distinct 
      subsets of DCs, myeloid DCs and plasmacytoid DCs, have been identified. Myeloid 
      DCs (mDCs) and plasmacytoid DCs (pDCs) are also called Type 1 DCs (DC1) and Type 
      2 DCs (DC2), respectively, because mDCs and pDCs were shown to preferentially 
      differentiate naive T cells into Th1 and Th2 cells, respectively. In asthma, it 
      can thus be speculated that an altered balance of mDCs to pDCs toward pDCs may 
      contribute to the Th2 polarization. To clarify this, we examined the numbers of 
      mDCs and pDCs in the peripheral blood of 44 patients with asthma and 38 normal 
      subjects, using multicolor flow cytometry. We found that the patients with asthma 
      had a significantly higher number of pDCs, resulting in a significant decrease in 
      the ratio of mDCs to pDCs compared with normal subjects. These data indicate that 
      the patients with asthma had a polarization of the mDC:pDC balance toward pDCs, 
      which may be involved in producing the Th2-dominant immune phenotype in asthma.
FAU - Matsuda, Hiroyuki
AU  - Matsuda H
AD  - Second Division, Department of Internal Medicine, and Department of Dermatology, 
      Hamamatsu University School of Medicine, Hamamatsu, Japan.
FAU - Suda, Takafumi
AU  - Suda T
FAU - Hashizume, Hideo
AU  - Hashizume H
FAU - Yokomura, Koushi
AU  - Yokomura K
FAU - Asada, Kazuhiro
AU  - Asada K
FAU - Suzuki, Kenichiro
AU  - Suzuki K
FAU - Chida, Kingo
AU  - Chida K
FAU - Nakamura, Hirotoshi
AU  - Nakamura H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (Interleukin-3)
RN  - 143011-72-7 (Granulocyte Colony-Stimulating Factor)
SB  - IM
MH  - Adult
MH  - Asthma/*blood/immunology
MH  - Blood Cell Count
MH  - Dendritic Cells/*classification/immunology
MH  - Female
MH  - Flow Cytometry
MH  - Granulocyte Colony-Stimulating Factor/blood
MH  - Humans
MH  - Interleukin-3/blood
MH  - Male
EDAT- 2002/10/16 04:00
MHDA- 2003/05/13 05:00
CRDT- 2002/10/16 04:00
PHST- 2002/10/16 04:00 [pubmed]
PHST- 2003/05/13 05:00 [medline]
PHST- 2002/10/16 04:00 [entrez]
AID - 10.1164/rccm.2110066 [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 2002 Oct 15;166(8):1050-4. doi: 10.1164/rccm.2110066.