PMID- 12383022
OWN - NLM
STAT- MEDLINE
DCOM- 20030303
LR  - 20191106
IS  - 1175-2203 (Print)
IS  - 1175-2203 (Linking)
VI  - 2
IP  - 3
DP  - 2002
TI  - Genetic analyses in asthma: current concepts and future directions.
PG  - 155-66
AB  - Asthma is a complex genetic disorder with a heterogeneous phenotype, largely 
      attributed to the interactions among many genes and between these genes and the 
      environment. Numerous loci and candidate genes have been reported to show linkage 
      and association of asthma and the asthma-associated phenotypes, atopy, elevated 
      immunoglobulin E (IgE) levels, and bronchial hyper-responsiveness to alleles of 
      microsatellite markers and single nucleotide polymorphisms (SNPs) within specific 
      cytokine/chemokine, and IgE regulating genes. While many studies reporting these 
      observations are compelling, only one asthma gene conferring high risk has been 
      mapped. In this review, we present studies that support linkage and/or 
      associations to the various genetic loci and genes in asthma. The first 
      genome-wide scan for linkage to quantitative traits underlying asthma identified 
      linkage on chromosome 4q, 6, 7, 11q, 13q and 16. A genome scan in American 
      families from three racial groups revealed linkage to chromosome 2q, 5q, 6p, 12q, 
      13q and 14q. A two-stage scan in Hutterite families from the US found linkage on 
      chromosome 5q, 12q, 19q and 21q. A screen in German families identified linkage 
      to asthma on chromosome 2q, 6p, 9 and 12q and a two-stage genome scan in French 
      families found replicated linkage on chromosomes 1p, 12q and 17q. A study of 
      asthma in Finland showed linkage to high IgE on 7q14. Apart from a European 
      linkage study of 199 families with atopic dermatitis, which demonstrated 
      significant linkage to chromosome 3q21, three other studies have reported linkage 
      results of genome-wide significance, including a linkage study in 175 Icelandic 
      asthma families (14q24), a study in 533 Chinese families with bronchial 
      hyper-responsiveness (chromosome 2) and a study in 47 Japanese families with 
      mite-sensitive atopic asthma (5q31), suggesting that these regions may harbor 
      genes contributing to the development of asthma and allergies. While significant 
      progress has been made in the field of asthma genetics in the past decade, the 
      clinical implications of the genes and genetic variations within the numerous 
      candidate asthma genes that have been found to associate with the expression of 
      the asthmatic phenotype, remain undetermined.
FAU - Hakonarson, Hakon
AU  - Hakonarson H
AD  - Division of Respiratory and Pharmacogenomics Research, deCODE Genetics, Inc., 
      Reykjavik, Iceland.
FAU - Halapi, Eva
AU  - Halapi E
LA  - eng
GR  - HL 59906/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - New Zealand
TA  - Am J Pharmacogenomics
JT  - American journal of pharmacogenomics : genomics-related research in drug 
      development and clinical practice
JID - 100967746
SB  - IM
MH  - Asthma/*genetics
MH  - Databases, Genetic/statistics & numerical data
MH  - Genetic Linkage/*genetics
MH  - Humans
RF  - 140
EDAT- 2002/10/18 04:00
MHDA- 2003/03/04 04:00
CRDT- 2002/10/18 04:00
PHST- 2002/10/18 04:00 [pubmed]
PHST- 2003/03/04 04:00 [medline]
PHST- 2002/10/18 04:00 [entrez]
AID - 020301 [pii]
AID - 10.2165/00129785-200202030-00001 [doi]
PST - ppublish
SO  - Am J Pharmacogenomics. 2002;2(3):155-66. doi: 10.2165/00129785-200202030-00001.