PMID- 12383494
OWN - NLM
STAT- MEDLINE
DCOM- 20030501
LR  - 20190922
IS  - 1570-0232 (Print)
IS  - 1570-0232 (Linking)
VI  - 780
IP  - 1
DP  - 2002 Nov 15
TI  - Simultaneous detection of amphetamine-like drugs with headspace solid-phase 
      microextraction and gas chromatography-mass spectrometry.
PG  - 183-92
AB  - A headspace solid-phase microextraction and gas chromatography-mass spectrometry 
      (HS-SPME-GC-MS) procedure for the simultaneous detection of 
      methylen-dioxyamphetamine (MDA), methylen-dioxymethamphetamine (MDMA), 
      methylen-dioxyethamphetamine (MDE) and 
      N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine (MBDB) in hair has been developed. 
      This method is suitable for the separation of primary and secondary amines, is 
      reproducible, is not time consuming, requires small quantities of sample and does 
      not require any derivatization. It provides sufficient sensitivity and 
      specificity, with limits of detection (LOD) and limits of quantitation (LOQ) for 
      each substance of <0.7 and 1.90 ng/mg, respectively. Intra- and inter-day 
      precision were within 2 and 10%, respectively. This method is suitable for 
      routine clinical, epidemiological and forensic purposes and can be used for the 
      preliminary screening of many other substances (amphetamine, methamphetamine, 
      ketamine, ephedrine, nicotine, phencyclidine, methadone) in hair and other 
      biological matrices such as saliva, urine and blood. We also describe the first 
      application of this HS-SPME-GC-MS procedure to the analysis of hair and saliva 
      samples from young people attending a disco in the Rome area. All positive hair 
      samples were confirmed by the gas chromatography-mass-mass (GC-MS(2)) technique 
      in positive chemical ionization (PCI) mode. Some examples of the use of the 
      method in detecting different drugs are reported.
FAU - Gentili, Stefano
AU  - Gentili S
AD  - Clinical Biochemistry Department, Drug Abuse Section, Istituto Superiore di 
      Sanita, Viale Regina Elena 299, 00161, Rome, Italy.
FAU - Torresi, Alessio
AU  - Torresi A
FAU - Marsili, Remo
AU  - Marsili R
FAU - Chiarotti, Marcello
AU  - Chiarotti M
FAU - Macchia, Teodora
AU  - Macchia T
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Chromatogr B Analyt Technol Biomed Life Sci
JT  - Journal of chromatography. B, Analytical technologies in the biomedical and life 
      sciences
JID - 101139554
RN  - 0 (Amphetamines)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Amphetamines/*analysis
MH  - Calibration
MH  - Female
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Hair/*chemistry
MH  - Humans
MH  - Male
MH  - Sensitivity and Specificity
EDAT- 2002/10/18 04:00
MHDA- 2003/05/02 05:00
CRDT- 2002/10/18 04:00
PHST- 2002/10/18 04:00 [pubmed]
PHST- 2003/05/02 05:00 [medline]
PHST- 2002/10/18 04:00 [entrez]
AID - S1570023202005226 [pii]
AID - 10.1016/s1570-0232(02)00522-6 [doi]
PST - ppublish
SO  - J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Nov 15;780(1):183-92. doi: 
      10.1016/s1570-0232(02)00522-6.