PMID- 12383648
OWN - NLM
STAT- MEDLINE
DCOM- 20030124
LR  - 20190901
IS  - 0165-2427 (Print)
IS  - 0165-2427 (Linking)
VI  - 89
IP  - 3-4
DP  - 2002 Oct 28
TI  - Levamisole is a potent enhancer of gilthead seabream natural cytotoxic activity.
PG  - 169-74
AB  - Gilthead seabream (Sparus aurata L.) head-kidney (HK) leucocytes were incubated 
      with 10(3) to 10(-4) ng levamisole/ml for 4, 24 or 48 h and then assayed for 
      their natural cytotoxic activity against xenogeneic tumor cells. This activity 
      was slightly increased after 24 h of incubation. In a second experiment, fish 
      specimens were fed 0, 75, 150 or 300 mg levamisole/kg diet for 10 consecutive 
      days. The fish were then fed a commercial non-supplemented diet and sampled 0, 1, 
      2, 3, 4 and 6 weeks post-administration of levamisole. The cytotoxic activity was 
      found increased along the experiment and remained greatly enhanced at the end. In 
      conclusion, levamisole enhanced seabream natural cytotoxic cell activity both in 
      vitro and in vivo and had a great and lasting action when administered by 
      feeding.
CI  - Copyright 2002 Elsevier Science B.V.
FAU - Cuesta, A
AU  - Cuesta A
AD  - Department of Cell Biology, Faculty of Biology, University of Murcia, 30100 
      Murcia, Spain.
FAU - Esteban, M A
AU  - Esteban MA
FAU - Meseguer, J
AU  - Meseguer J
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Vet Immunol Immunopathol
JT  - Veterinary immunology and immunopathology
JID - 8002006
RN  - 0 (Adjuvants, Immunologic)
RN  - 2880D3468G (Levamisole)
SB  - IM
MH  - *Adjuvants, Immunologic/administration & dosage/pharmacology
MH  - Animal Feed
MH  - Animals
MH  - Cytotoxicity, Immunologic/drug effects/*immunology
MH  - Diet
MH  - Fish Diseases/immunology/prevention & control
MH  - Immunity, Innate/*immunology
MH  - Leukocytes/*immunology
MH  - Levamisole/administration & dosage/*immunology/pharmacology
MH  - Logistic Models
MH  - Sea Bream/*immunology
MH  - Time Factors
MH  - Tumor Cells, Cultured
EDAT- 2002/10/18 04:00
MHDA- 2003/01/25 04:00
CRDT- 2002/10/18 04:00
PHST- 2002/10/18 04:00 [pubmed]
PHST- 2003/01/25 04:00 [medline]
PHST- 2002/10/18 04:00 [entrez]
AID - S0165242702002209 [pii]
AID - 10.1016/s0165-2427(02)00220-9 [doi]
PST - ppublish
SO  - Vet Immunol Immunopathol. 2002 Oct 28;89(3-4):169-74. doi: 
      10.1016/s0165-2427(02)00220-9.