PMID- 12383970
OWN - NLM
STAT- MEDLINE
DCOM- 20021030
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 948
IP  - 1-2
DP  - 2002 Sep 6
TI  - Testosterone enhances aggression of wild-type mice but not those deficient in 
      type I 5alpha-reductase.
PG  - 165-70
AB  - Testosterone's (T) aggression-enhancing effects may be mediated in part by its 
      5alpha-reduced, 3-hydroxysteroid dehydrogenized metabolite 
      5alpha-androstane-3alpha,17beta-diol (3alpha-diol). To test this hypothesis, in 
      Expt. 1 gonadectomized (gdx) C21 mice were administered T, 3alpha-diol, or 
      vehicle and were observed in the resident intruder test of aggression 1 h later. 
      C21 mice administered androgens had significantly higher incidences of aggression 
      than did vehicle-administered mice. In Expt. 2, wild-type mice and mice deficient 
      in the 5alpha-reductase type I enzyme were administered T or vehicle and tested 1 
      h later in the resident intruder paradigm. Wild-type mice administered T had 
      significantly shorter latencies and greater incidences of aggression than did 
      5alpha-reductase type I knockout mice administered T or vehicle-administered 
      mice. Data from Expt. 1 are consistent with T and 3alpha-diol having similar 
      aggression-enhancing effects, and results of Expt. 2 suggest that the inability 
      to metabolize T to its 5alpha-reduced products may attenuate some 
      aggression-enhancing effects of mice in the resident intruder test of aggression.
CI  - Copyright 2002 Elsevier Science B.V.
FAU - Frye, Cheryl A
AU  - Frye CA
AD  - Department of Psychology, The University at Albany-SUNY, 1400 Washington Avenue, 
      Albany, NY 12222, USA. cafrye@cnsunix.albany.edu
FAU - Rhodes, Madeline E
AU  - Rhodes ME
FAU - Walf, Alicia
AU  - Walf A
FAU - Harney, Jacob P
AU  - Harney JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 25126-76-5 (Androstane-3,17-diol)
RN  - 3XMK78S47O (Testosterone)
RN  - EC 1.3.99.5 (3-Oxo-5-alpha-Steroid 4-Dehydrogenase)
SB  - IM
MH  - 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/*deficiency/genetics
MH  - Aggression/*drug effects/*physiology
MH  - Androstane-3,17-diol/pharmacology
MH  - Animals
MH  - Behavior, Animal/*drug effects/physiology
MH  - Male
MH  - Mice
MH  - Mice, Knockout
MH  - Orchiectomy
MH  - Reaction Time/drug effects/physiology
MH  - Social Behavior
MH  - Testosterone/*pharmacology
EDAT- 2002/10/18 04:00
MHDA- 2002/11/01 04:00
CRDT- 2002/10/18 04:00
PHST- 2002/10/18 04:00 [pubmed]
PHST- 2002/11/01 04:00 [medline]
PHST- 2002/10/18 04:00 [entrez]
AID - S0006899302030767 [pii]
AID - 10.1016/s0006-8993(02)03076-7 [doi]
PST - ppublish
SO  - Brain Res. 2002 Sep 6;948(1-2):165-70. doi: 10.1016/s0006-8993(02)03076-7.