PMID- 123851
OWN - NLM
STAT- MEDLINE
DCOM- 19750807
LR  - 20190918
IS  - 0013-9432 (Print)
IS  - 0013-9432 (Linking)
VI  - 19
IP  - 4
DP  - 1975
TI  - Adaptation of red cell enzymes and intermediates in metabolic disorders.
PG  - 201-11
AB  - The metabolic activity of the red cell glycolytic pathway hexose monophosphate 
      shunt (HMP) with dependent glutathione system was studied in patients with 
      hyperthyroidism (n = 10), hyperlipoproteinemia (n = 16), hypoglycemia (n = 25) 
      and hyperglycemia (n = 23). In uncontrolled diabetics and patients with 
      hyperthyroidism the mean value of glucose phosphate isomerase (GPI), 
      glucose-6-phosphate dehydrogenase (G-6-PD), glutathione reductase (GR) was 
      increased, whereas these enzyme activities were reduced in patients with 
      hypoglycemia. Apart from a few values of hexokinase (HK) which were lower than 
      normal the results in hyperlipoproteinemia patients remained essentially 
      unchanged, including the intermediates such as 2,3-diphosphoglycerate (2,3-DPG), 
      adenosine triphosphate (ATP) and reduced glutathione (GSH). While increased rates 
      of 2,3-DPG and ATP in hypoglycemia patients were obtained, these substrates were 
      markedly reduced in diabetics.
FAU - Goebel, K M
AU  - Goebel KM
FAU - Goebel, F D
AU  - Goebel FD
FAU - Neitzert, A
AU  - Neitzert A
FAU - Hausmann, L
AU  - Hausmann L
FAU - Schneider, J
AU  - Schneider J
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Enzyme
JT  - Enzyme
JID - 1262265
RN  - EC 1.1.1.49 (Glucosephosphate Dehydrogenase)
RN  - EC 1.8.1.7 (Glutathione Reductase)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - EC 2.7.1.11 (Phosphofructokinase-1)
RN  - EC 2.7.1.40 (Pyruvate Kinase)
RN  - EC 5.3.1.9 (Glucose-6-Phosphate Isomerase)
SB  - IM
MH  - Diabetes Mellitus/*enzymology
MH  - Erythrocytes/*enzymology
MH  - Glucose-6-Phosphate Isomerase/blood
MH  - Glucosephosphate Dehydrogenase/blood
MH  - Glutathione Reductase/blood
MH  - Hexokinase/blood
MH  - Humans
MH  - Hyperglycemia/enzymology
MH  - Hyperlipidemias/*enzymology/*genetics
MH  - Hyperthyroidism/*enzymology
MH  - Hypoglycemia/*enzymology
MH  - Phosphofructokinase-1/blood
MH  - Pyruvate Kinase/blood
EDAT- 1975/01/01 00:00
MHDA- 1975/01/01 00:01
CRDT- 1975/01/01 00:00
PHST- 1975/01/01 00:00 [pubmed]
PHST- 1975/01/01 00:01 [medline]
PHST- 1975/01/01 00:00 [entrez]
AID - 10.1159/000458993 [doi]
PST - ppublish
SO  - Enzyme. 1975;19(4):201-11. doi: 10.1159/000458993.