PMID- 12385636
OWN - NLM
STAT- MEDLINE
DCOM- 20030124
LR  - 20190916
IS  - 0033-7587 (Print)
IS  - 0033-7587 (Linking)
VI  - 158
IP  - 5
DP  - 2002 Nov
TI  - Stable chromosome aberrations in the lymphocytes of a population living in the 
      vicinity of the Semipalatinsk nuclear test site.
PG  - 591-6
AB  - SalomaTranslocation analysis using FISH (fluorescence in situ hybridization) 
      chromosome painting was performed to evaluate the magnitude of exposure to 
      ionizing radiation among the human population living close to the Semipalatinsk 
      nuclear test site in Kazakhstan. We studied two generations of people living in 
      villages that were in the path of the radioactive cloud from the first Soviet 
      surface nuclear test performed in August 1949 and from later tests. The older 
      generation (P(0)) lived in the area at the time of testing, and the younger 
      generation (F(1)) was exposed to smaller doses from the residual fallout and 
      later tests. In both P(0) and F(1) generations, similar translocation frequencies 
      were observed in persons living in either the Semipalatinsk area or a 
      noncontaminated area. Assuming translocation stability in peripheral blood 
      lymphocytes over several decades, these findings suggest that on average, the 
      magnitude of exposure of this cohort in the Semipalatinsk area has been 
      considerably smaller than that reported in the literature. Previously reported 
      doses of the order of 1-4.5 Gy (mean 2.9 Gy in the P(0) generation) cannot be 
      confirmed by the present data.
FAU - Salomaa, Sisko
AU  - Salomaa S
AD  - STUK-Radiation and Nuclear Safety Authority, 00881 Helsinki, Finland.
FAU - Lindholm, Carita
AU  - Lindholm C
FAU - Tankimanova, Maira K
AU  - Tankimanova MK
FAU - Mamyrbaeva, Zaure Zh
AU  - Mamyrbaeva ZZh
FAU - Koivistoinen, Armi
AU  - Koivistoinen A
FAU - Hulten, Maj
AU  - Hulten M
FAU - Mustonen, Riitta
AU  - Mustonen R
FAU - Dubrova, Yuri E
AU  - Dubrova YE
FAU - Bersimbaev, Rakhmetkaji I
AU  - Bersimbaev RI
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Radiat Res
JT  - Radiation research
JID - 0401245
RN  - 0 (Radioactive Fallout)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Chromosome Aberrations/*radiation effects
MH  - Environmental Exposure
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Kazakhstan/epidemiology
MH  - Lymphocytes/*metabolism/*radiation effects
MH  - Male
MH  - Middle Aged
MH  - Radioactive Fallout/*adverse effects
MH  - Regression Analysis
MH  - Sex Characteristics
MH  - Smoking
EDAT- 2002/10/19 04:00
MHDA- 2003/01/25 04:00
CRDT- 2002/10/19 04:00
PHST- 2002/10/19 04:00 [pubmed]
PHST- 2003/01/25 04:00 [medline]
PHST- 2002/10/19 04:00 [entrez]
AID - 10.1667/0033-7587(2002)158[0591:scaitl]2.0.co;2 [doi]
PST - ppublish
SO  - Radiat Res. 2002 Nov;158(5):591-6. doi: 
      10.1667/0033-7587(2002)158[0591:scaitl]2.0.co;2.