PMID- 12387364
OWN - NLM
STAT- MEDLINE
DCOM- 20030221
LR  - 20191106
IS  - 0161-813X (Print)
IS  - 0161-813X (Linking)
VI  - 23
IP  - 3
DP  - 2002 Sep
TI  - Effects of perinatal exposure to a polybrominated diphenyl ether (PBDE 99) on 
      mouse neurobehavioural development.
PG  - 375-84
AB  - Polybrominated diphenyl ethers (PBDEs), a class of widely used flame retardants, 
      are extensively diffused in the environment as shown by several studies on 
      sentinel animal species, as well as humans. Of particular concern are the 
      reported high levels of PBDEs in human milk, as almost no information is 
      available on their potential effects on developing organisms. We investigated the 
      effects of perinatal PBDE exposure on mouse neurobehavioural development. 
      2,2',4,4,5-pentabromodiphenylether (PBDE 99; 0.6, 6 and 30 mg/kg per day) was 
      administered daily to CD-1 Swiss females by gavage from gestational day (GD) 6 to 
      postnatal day (PND) 21. Aroclor 1254 (A1254; 6 mg/ kg per day), a PCB mixture, 
      was administered following the same schedule and served as a positive controL The 
      PBDE 99 medium dose had an effect on litter viability. Sensori-motor development 
      analysis (PNDs 2-20) revealed a delayed appearance of climbing response in the 
      PBDE 99 high-dose group. On PND 11, the homing test revealed a trend for treated 
      animals, particularly the A1254 group, to be more active than controls. This 
      activity level alteration was strongly increased on PNDs 34 and 60 in an 
      open-field arena. On PND 60, treated mice showed also an altered thigmotaxis, 
      spending more time in the centre of the arena than controls. At adulthood, A1254 
      treated mice were still hyperactive, whereas the PBDE 99 groups tended to be 
      hypoactive. These findings showed that perinatal exposure to PBDE 99 produces 
      several behavioural alterations and that its effects are not always similar to 
      those of A1254. The possibility of exposure of neonates to PBDEs warrants further 
      studies to characterise their developmental neurotoxicity.
FAU - Branchi, Igor
AU  - Branchi I
AD  - Department of Pharmacology of Natural Substances and General Physiology, 
      University of Rome La Sapienza, Italy. branchi@iss.it
FAU - Alleva, Enrico
AU  - Alleva E
FAU - Costa, Lucio G
AU  - Costa LG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Neurotoxicology
JT  - Neurotoxicology
JID - 7905589
RN  - 0 (Flame Retardants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Brominated)
RN  - 0 (Phenyl Ethers)
RN  - 0 (Polybrominated Biphenyls)
RN  - 11097-69-1 (Chlorodiphenyl (54% Chlorine))
RN  - 7REL09ZX35 (pentabromodiphenyl ether)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Body Weight/drug effects
MH  - Chlorodiphenyl (54% Chlorine)/toxicity
MH  - Embryonic and Fetal Development/drug effects
MH  - Female
MH  - Flame Retardants/*toxicity
MH  - Hair/growth & development
MH  - Halogenated Diphenyl Ethers
MH  - Homing Behavior/drug effects
MH  - Hydrocarbons, Brominated/*toxicity
MH  - Male
MH  - Mice
MH  - Motor Activity/drug effects
MH  - Nervous System/*growth & development
MH  - Phenyl Ethers/*toxicity
MH  - Polybrominated Biphenyls
MH  - Postural Balance/drug effects
MH  - Pregnancy
MH  - Vocalization, Animal/drug effects
EDAT- 2002/10/22 04:00
MHDA- 2003/02/22 04:00
CRDT- 2002/10/22 04:00
PHST- 2002/10/22 04:00 [pubmed]
PHST- 2003/02/22 04:00 [medline]
PHST- 2002/10/22 04:00 [entrez]
AID - S0161-813X(02)00078-5 [pii]
AID - 10.1016/s0161-813x(02)00078-5 [doi]
PST - ppublish
SO  - Neurotoxicology. 2002 Sep;23(3):375-84. doi: 10.1016/s0161-813x(02)00078-5.