PMID- 12388137
OWN - NLM
STAT- MEDLINE
DCOM- 20030110
LR  - 20131121
IS  - 0193-1849 (Print)
IS  - 0193-1849 (Linking)
VI  - 284
IP  - 1
DP  - 2003 Jan
TI  - Effects of an oral androgen on muscle and metabolism in older, community-dwelling 
      men.
PG  - E120-8
AB  - To determine whether oxymetholone increases lean body mass (LBM) and skeletal 
      muscle strength in older persons, 31 men 65-80 yr of age were randomized to 
      placebo (group 1) or 50 mg (group 2) or 100 mg (group 3) daily for 12 wk. For the 
      three groups, total LBM increased by 0.0 +/- 0.6, 3.3 +/- 1.2 (P < 0.001), and 
      4.2 +/- 2.4 kg (P < 0.001), respectively. Trunk fat decreased by 0.2 +/- 0.4, 1.7 
      +/- 1.0 (P = 0.018), and 2.2 +/- 0.9 kg (P = 0.005) in groups 1, 2, and 3, 
      respectively. Relative increases in 1-repetition maximum (1-RM) strength for 
      biaxial chest press of 8.2 +/- 9.2 and 13.9 +/- 8.1% in the two active treatment 
      groups were significantly different from the change (-0.8 +/- 4.3%) for the 
      placebo group (P < 0.03). For lat pull-down, 1-RM changed by -0.6 +/- 8.3, 8.8 
      +/- 15.1, and 18.4 +/- 21.0% for the groups, respectively (1-way ANOVA, P = 
      0.019). The pattern of changes among the groups for LBM and upper-body strength 
      suggested that changes might be related to dose. Alanine aminotransferase 
      increased by 72 +/- 67 U/l in group 3 (P < 0.001), and HDL-cholesterol decreased 
      by -19 +/- 9 and -23 +/- 18 mg/dl in groups 2 and 3, respectively (P = 0.04 and P 
      = 0.008). Thus oxymetholone improved LBM and maximal voluntary muscle strength 
      and decreased fat mass in older men.
FAU - Schroeder, E Todd
AU  - Schroeder ET
AD  - Department of Medicine, Keck School of Medicine, University of Southern 
      California, Los Angeles 90033, USA.
FAU - Singh, Atam
AU  - Singh A
FAU - Bhasin, Shalender
AU  - Bhasin S
FAU - Storer, Thomas W
AU  - Storer TW
FAU - Azen, Colleen
AU  - Azen C
FAU - Davidson, Tina
AU  - Davidson T
FAU - Martinez, Carmen
AU  - Martinez C
FAU - Sinha-Hikim, Indrani
AU  - Sinha-Hikim I
FAU - Jaque, S Victoria
AU  - Jaque SV
FAU - Terk, Michael
AU  - Terk M
FAU - Sattler, Fred R
AU  - Sattler FR
LA  - eng
GR  - 1R01 AG-14369-01/AG/NIA NIH HHS/United States
GR  - 1R01 DK-49308-04/DK/NIDDK NIH HHS/United States
GR  - 1R01 DK-59627-01/DK/NIDDK NIH HHS/United States
GR  - 2R01 DK-49296-02A/DK/NIDDK NIH HHS/United States
GR  - G12 RR-03026/RR/NCRR NIH HHS/United States
GR  - M01 RR-430/RR/NCRR NIH HHS/United States
GR  - P20 RR-11145/RR/NCRR NIH HHS/United States
GR  - U01-DK-54047/DK/NIDDK NIH HHS/United States
GR  - U54 RR-14616/RR/NCRR NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20020924
PL  - United States
TA  - Am J Physiol Endocrinol Metab
JT  - American journal of physiology. Endocrinology and metabolism
JID - 100901226
RN  - 0 (Anabolic Agents)
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
RN  - 0 (Placebos)
RN  - 0 (Sex Hormone-Binding Globulin)
RN  - 3XMK78S47O (Testosterone)
RN  - 9002-67-9 (Luteinizing Hormone)
RN  - L76T0ZCA8K (Oxymetholone)
SB  - IM
MH  - Absorptiometry, Photon
MH  - Aged
MH  - Aged, 80 and over
MH  - Anabolic Agents/*administration & dosage
MH  - Biomechanical Phenomena
MH  - Blood Glucose/analysis
MH  - Body Composition/*drug effects
MH  - Double-Blind Method
MH  - Fasting
MH  - Humans
MH  - Insulin/blood
MH  - Lipids/blood
MH  - Luteinizing Hormone/blood
MH  - Male
MH  - Muscle, Skeletal/*drug effects/*physiology
MH  - Nutrition Assessment
MH  - Oxymetholone/*administration & dosage
MH  - Placebos
MH  - Sex Hormone-Binding Globulin/analysis
MH  - Testosterone/blood
EDAT- 2002/10/22 04:00
MHDA- 2003/01/11 04:00
CRDT- 2002/10/22 04:00
PHST- 2002/10/22 04:00 [pubmed]
PHST- 2003/01/11 04:00 [medline]
PHST- 2002/10/22 04:00 [entrez]
AID - 00363.2002 [pii]
AID - 10.1152/ajpendo.00363.2002 [doi]
PST - ppublish
SO  - Am J Physiol Endocrinol Metab. 2003 Jan;284(1):E120-8. doi: 
      10.1152/ajpendo.00363.2002. Epub 2002 Sep 24.