PMID- 12390711
OWN - NLM
STAT- MEDLINE
DCOM- 20021126
LR  - 20060302
IS  - 1000-2588 (Print)
IS  - 1000-2588 (Linking)
VI  - 22
IP  - 5
DP  - 2002 May
TI  - Correlation between angiotensin II type 1 receptor gene polymorphism and type 2 
      diabetes mellitus complicated by hypertension.
PG  - 444-6
AB  - OBJECTIVE: To elucidate the correlation between angiotensin II type 1 receptor 
      (AT1R) gene polymorphism and type 2 diabetes mellitus (T2DM) complicated by 
      hypertension. METHODS: AT1R gene polymorphism was determined by PCR in 132 T2DM 
      patients complicated by hypertension and 107 normotensive T2DM patients. RESULTS: 
      The frequencies of AA and AC genotypes in the 2 groups were 88.79% vs 96.97% and 
      11.21% vs 3.03% respectively, and those for A and C allele were 94.39% vs 98.48% 
      and 5.61% vs 1.51%, showing significant difference between the 2 groups (P<0.05). 
      It was suggested that AT1R gene polymorphism was associated with T2DM complicated 
      by hypertension, and the patients had significantly prolonged courses of DM when 
      complicated by hypertension. Normotensive DM patients did not differ from DM 
      patients with only elevated diastolic blood pressure in terms of AT1R-A1166-C 
      gene polymorphism, but showed significant difference from DM patients with 
      elevated systolic blood pressure. CONCLUSION: AT1R gene contributed to T2DM 
      complicated by hypertension, but is only associated with cases of elevated 
      systolic blood pressure.
FAU - Xue, Yao-Ming
AU  - Xue YM
AD  - Department of Endocrinology, Nanfang Hospital, First Military Medical University, 
      Guangzhou 510515, China.
FAU - Zhou, Lin
AU  - Zhou L
FAU - Luo, Ren
AU  - Luo R
LA  - eng
PT  - Journal Article
PL  - China
TA  - Di Yi Jun Yi Da Xue Xue Bao
JT  - Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA
JID - 9426110
RN  - 0 (Receptor, Angiotensin, Type 1)
RN  - 0 (Receptors, Angiotensin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Blood Pressure/physiology
MH  - Diabetes Mellitus, Type 2/complications/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Hypertension/*complications/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Mutation
MH  - Polymorphism, Genetic
MH  - Receptor, Angiotensin, Type 1
MH  - Receptors, Angiotensin/*genetics
EDAT- 2002/10/23 04:00
MHDA- 2002/11/28 04:00
CRDT- 2002/10/23 04:00
PHST- 2002/10/23 04:00 [pubmed]
PHST- 2002/11/28 04:00 [medline]
PHST- 2002/10/23 04:00 [entrez]
PST - ppublish
SO  - Di Yi Jun Yi Da Xue Xue Bao. 2002 May;22(5):444-6.