PMID- 12390747
OWN - NLM
STAT- MEDLINE
DCOM- 20021119
LR  - 20071108
IS  - 1000-2588 (Print)
IS  - 1000-2588 (Linking)
VI  - 22
IP  - 4
DP  - 2002 Apr
TI  - [Panel reactive antibody screening and human leukocyte antigen typing in 1 700 
      cases of renal transplantation].
PG  - 360-2
AB  - OBJECTIVE: To evaluate the role of panel reactive antibody (PRA) screening and 
      human leukocyte antigen (HLA) typing in renal transplantation. METHODS: PRA 
      screening and HLA typing were performed in 1 700 patients eligible for the first 
      group of renal transplantation who had 3 to 6 HLA matches in HLA-A, B and DR with 
      the donor, and in cases positive for PRA, plasma exchange was conducted. Another 
      423 patients who did not receive PRA screening or HLA typing constituted the 
      second group. The changes of immune variables, incidences of acute rejection and 
      the effect of HLA-A, B, DR matching on long-term graft survival were observed. 
      RESULTS: In 1 700 cases of group 1, post-transplantation CsA dose was reduced to 
      5 to 7 mg*kg(-1)*d(-1) and the graft function recovery time ranged from 2 to 16 
      d, averaging 5 d. Acute graft rejection occurred in 252 (14.8%) cases, but no 
      hyper-acute rejection was observed. The 1-, 3- and 5-year patient/graft survival 
      rates were 98.6%/96.7%, 93.1%/87.3% and 88.1%/83.6% respectively. In group 2, CsA 
      dose ranged from 8 to 12 mg*kg(-1)*d(-1) and the graft function recovery time was 
      4 to 30 d, averaging 13 d. Hyper-acute rejection occurred in 9 (2.1%) and acute 
      rejection in 198 (46.8%) cases, and the 1-, 3- and 5-year patient/graft survival 
      rates were 86.7%/76.3%, 72.5%/67.9% and 69.5%/59.3% respectively. CONCLUSIONS: 
      Negative PRA and good HLA matching can eliminate the incidences of hyper-acute 
      rejection, decrease the rate of acute rejection and improve both patient and 
      graft survival rates.
FAU - Yu, Li-Xin
AU  - Yu LX
AD  - Department of Kidney Transplantation, Nanfang Hospital, First Military Medical 
      University, Guangzhou 510515, China.
FAU - Yao, Bing
AU  - Yao B
FAU - Ye, Gui-Rong
AU  - Ye GR
FAU - Du, Chuan-Fu
AU  - Du CF
FAU - Deng, Wen-Feng
AU  - Deng WF
FAU - Xu, Jian
AU  - Xu J
FAU - Ma, Jun-Jie
AU  - Ma JJ
FAU - Fu, Shoa-Jie
AU  - Fu SJ
FAU - Xiao, Lu-Lu
AU  - Xiao LL
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Di Yi Jun Yi Da Xue Xue Bao
JT  - Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA
JID - 9426110
RN  - 0 (Antibodies)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antibodies/immunology
MH  - Child
MH  - Female
MH  - Graft Rejection/*immunology/mortality
MH  - HLA Antigens/*classification/immunology
MH  - Humans
MH  - Kidney Transplantation/*immunology
MH  - Male
MH  - Middle Aged
EDAT- 2002/10/23 04:00
MHDA- 2002/11/26 04:00
CRDT- 2002/10/23 04:00
PHST- 2002/10/23 04:00 [pubmed]
PHST- 2002/11/26 04:00 [medline]
PHST- 2002/10/23 04:00 [entrez]
PST - ppublish
SO  - Di Yi Jun Yi Da Xue Xue Bao. 2002 Apr;22(4):360-2.