PMID- 12390787
OWN - NLM
STAT- MEDLINE
DCOM- 20021125
LR  - 20080401
IS  - 1000-2588 (Print)
IS  - 1000-2588 (Linking)
VI  - 22
IP  - 3
DP  - 2002 Mar
TI  - [Normal pregnancy in a woman having had a child with trisomy 21 syndrome before: 
      application of preimplantation genetic diagnosis].
PG  - 269-71
AB  - OBJECTIVE: To study the value of preimplantation genetic diagnosis (PGD) before 
      pregnancy for couples who are exposed to high risk of trisomy 21 syndrome in 
      their progenies to obtain birth of healthy child by in vitro fertilization 
      procedures. METHODS: Conventional hormone replacement treatment with 
      intracytoplasmic sperm injection (ISCI) was administered for ovum fertilization. 
      One or two cells (blastomeres) were aspirated from the preimplantation embryo 
      that had grown to 6 to 10 cells (day 3 post fertilization) for PGD with 
      fluorescence in situ hybridization (FISH), and 3 embryos with normal chromosome 
      were transferred into the uterus. RESULTS: PGD was carried out in a total of 8 
      embryos with valid diagnoses in 7, of which 6 were identified as normal embryos 
      and 1 had trisomy 21 syndrome. Pregnancy was obtained that resulted in the birth 
      of a healthy baby. CONCLUSION: Detection of chromosomal abnormalities such as 
      trisomy 21 syndrome is feasible for PGD with FISH.
FAU - Luo, Chen
AU  - Luo C
AD  - Center of Assisted Reproduction, Nanfang Hospital, First Military Medical 
      University, Guangzhou 510515, China.
FAU - Xing, Fu-Qi
AU  - Xing FQ
FAU - Luo, Shen-Qiu
AU  - Luo SQ
LA  - chi
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Di Yi Jun Yi Da Xue Xue Bao
JT  - Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA
JID - 9426110
SB  - IM
MH  - Adult
MH  - Down Syndrome/*genetics
MH  - Fatal Outcome
MH  - Female
MH  - Fertilization in Vitro
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infant, Newborn
MH  - Male
MH  - Pregnancy
MH  - *Preimplantation Diagnosis
EDAT- 2002/10/23 04:00
MHDA- 2002/11/26 04:00
CRDT- 2002/10/23 04:00
PHST- 2002/10/23 04:00 [pubmed]
PHST- 2002/11/26 04:00 [medline]
PHST- 2002/10/23 04:00 [entrez]
PST - ppublish
SO  - Di Yi Jun Yi Da Xue Xue Bao. 2002 Mar;22(3):269-71.