PMID- 12390864
OWN - NLM
STAT- MEDLINE
DCOM- 20030521
LR  - 20190513
IS  - 0006-3363 (Print)
IS  - 0006-3363 (Linking)
VI  - 67
IP  - 5
DP  - 2002 Nov
TI  - Do nonhuman primates comprise appropriate experimental models for studying the 
      function of human leukocyte antigen-G?
PG  - 1367-74
AB  - The expression and function of the human major histocompatibility complex (MHC) 
      class Ia genes, human leukocyte antigen (HLA)-A, -B, and -C, is well-established; 
      they are expressed in most nucleated cells and present endogenous peptides to 
      CD8+ T cells. However, MHC class Ib genes are poorly characterized and have 
      unknown functions. In humans, the best-characterized class Ib gene is HLA-G. This 
      gene has a restricted tissue expression of the mRNA and a unique pattern of 
      protein expression; it is expressed mainly in the extravillous cytotrophoblast 
      cells in the placenta. The function of HLA-G is not clear, but its presence at 
      the maternal-fetal interface suggests a role in protection of the semiallogeneic 
      fetus. Whereas functional studies using in vitro models and transgenic mice 
      provide useful insights regarding the potential function of this molecule, in 
      vivo studies cannot be performed in humans. Nonhuman primates that are closely 
      related to humans phylogenetically contain homologues of HLA-G. The MHC-G loci in 
      nonhuman primates appear to have diverged from the human HLA-G. However, in the 
      rhesus monkey (Macaca mulatta) and olive baboon (Papio anubis), a novel class 
      Ia-related locus has been described. This gene encodes glycoproteins with 
      characteristics that resemble those of HLA-G, including restricted tissue 
      distribution, alternative splicing of mRNA, truncated cytoplasmic domain, and 
      limited polymorphism. Thus, this molecule may be the functional homologue of 
      HLA-G, and these two species may comprise appropriate models for elucidating the 
      function of HLA-G.
FAU - Langat, Daudi K
AU  - Langat DK
AD  - Institute of Primate Research, Karen, Nairobi, Kenya.
FAU - Hunt, Joan S
AU  - Hunt JS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Biol Reprod
JT  - Biology of reproduction
JID - 0207224
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Animals
MH  - Cebidae/immunology
MH  - Female
MH  - Gene Expression
MH  - *Genes, MHC Class I
MH  - HLA Antigens/chemistry/*genetics/*metabolism
MH  - HLA-G Antigens
MH  - Haplorhini/immunology
MH  - Histocompatibility Antigens Class I/chemistry/*genetics/*metabolism
MH  - Humans
MH  - Maternal-Fetal Exchange/immunology
MH  - Pregnancy
MH  - Primates/*immunology
RF  - 75
EDAT- 2002/10/23 04:00
MHDA- 2003/05/22 05:00
CRDT- 2002/10/23 04:00
PHST- 2002/10/23 04:00 [pubmed]
PHST- 2003/05/22 05:00 [medline]
PHST- 2002/10/23 04:00 [entrez]
AID - 10.1095/biolreprod.102.005587 [doi]
PST - ppublish
SO  - Biol Reprod. 2002 Nov;67(5):1367-74. doi: 10.1095/biolreprod.102.005587.