PMID- 12391099
OWN - NLM
STAT- MEDLINE
DCOM- 20030620
LR  - 20161124
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 94
IP  - 1
DP  - 2003 Jan
TI  - Effects of obstructive sleep apnea on circulating ICAM-1, IL-8, and MCP-1.
PG  - 179-84
AB  - Obstructive sleep apnea syndrome (OSAS) is one of the most important risk factors 
      of cardiovascular disorders. In the treatment of OSAS, nasal continuous positive 
      airway pressure (nCPAP) has been widely used and found to be effective. In the 
      present study, we hypothesized that the hypoxic stress caused by obstructive 
      sleep apnea would increase circulating intercellular adhesion molecule-1 
      (ICAM-1), interleukin-8 (IL-8), and monocyte chemoattractant protein-1 (MCP-1) in 
      untreated OSAS patients compared with an age-matched control group. In addition, 
      we hypothesized that nCPAP may decrease OSAS-induced hypoxic stress and 
      mediators. To examine these hypotheses, we measured circulating ICAM-1 and IL-8 
      before and after nCPAP therapy in OSAS patients. We observed that nCPAP decreased 
      apnea, desaturation, and the circulating ICAM-1 and IL-8 levels in OSAS patients. 
      The circulating levels of ICAM-1, IL-8, and MCP-1 in untreated OSAS patients were 
      significantly greater than those in the controls. These observations suggest that 
      nCPAP therapy could reduce OSAS-induced hypoxia and generation of inflammatory 
      mediators. Treatment of OSAS using nCPAP can be, therefore, a potential approach 
      to decrease risk of the progression of OSAS-associated disorders.
FAU - Ohga, Eijiro
AU  - Ohga E
AD  - Department of Geriatric Medicine, Graduate School of Medicine, University of 
      Tokyo, Japan.
FAU - Tomita, Tetsuji
AU  - Tomita T
FAU - Wada, Hiroo
AU  - Wada H
FAU - Yamamoto, Hiroshi
AU  - Yamamoto H
FAU - Nagase, Takahide
AU  - Nagase T
FAU - Ouchi, Yasuyoshi
AU  - Ouchi Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20020927
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-8)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Chemokine CCL2/*blood
MH  - Humans
MH  - Hypoxia/blood/etiology
MH  - Intercellular Adhesion Molecule-1/*blood
MH  - Interleukin-8/*blood
MH  - Male
MH  - Middle Aged
MH  - Positive-Pressure Respiration
MH  - Sleep Apnea, Obstructive/*blood/complications/therapy
MH  - Stress, Physiological/blood/etiology
EDAT- 2002/10/23 04:00
MHDA- 2003/06/21 05:00
CRDT- 2002/10/23 04:00
PHST- 2002/10/23 04:00 [pubmed]
PHST- 2003/06/21 05:00 [medline]
PHST- 2002/10/23 04:00 [entrez]
AID - 00177.2002 [pii]
AID - 10.1152/japplphysiol.00177.2002 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2003 Jan;94(1):179-84. doi: 
      10.1152/japplphysiol.00177.2002. Epub 2002 Sep 27.