PMID- 12391521
OWN - NLM
STAT- MEDLINE
DCOM- 20021210
LR  - 20131121
IS  - 0003-2417 (Print)
IS  - 0003-2417 (Linking)
VI  - 51
IP  - 8
DP  - 2002 Aug
TI  - [Partial CO(2) rebreathing technique versus thermodilution: measurement of 
      cardiac output before and after operations with extracorporeal circulation].
PG  - 625-33
AB  - BACKGROUND: The NICO(2) monitor determines "pulmonary capillary blood flow" (Qpc) 
      and cardiac output (Qt) using the "partial CO(2) rebreathing technique". The 
      agreement between NICO(2) and thermodilution (TD) cardiac output was compared 
      before and after cardiac surgery with cardiopulmonary bypass (CBP). In addition, 
      the possibility of calculating the intrapulmonary shunt fraction (Qs/Qt) by 
      combining data from the NICO(2) monitor and the TD was investigated. METHODS: In 
      32 patients measurements were made following induction of anesthesia ("pre-CBP"), 
      30 min after weaning from CBP ("post-CBP"), and 6-8 h after surgery ("post-OP"). 
      Qt was determined by the NICO(2) monitor and TD, Qpc by the NICO(2) monitor, and 
      Qs/Qt(O(2)) from the standard formula. An intrapulmonary shunt was calculated 
      using Qpc(NICO(2)) and Qt(TD) according to the equation Qs/Qt=1-Qpc/Qt. 
      Bland-Altman and regression analysis techniques were used for statistical 
      evaluation. RESULTS: "Pre-CBP" there was a good agreement between Qt(NICO(2)) and 
      Qt(TD) with both a bias and precision of -0.13+/-0.46 l/min and a correlation of 
      r=0.88+/-0.47 ( p<0.001). In contrast, "post-CBP" and "post-OP" there was a lack 
      of agreement for Qt (bias and precision: 0.97+/-1.05 l/min and -0.33+/-0.8 l/min, 
      respectively). Regarding the shunt calculations no significant correlations 
      between methods could be found. CONCLUSION: Cardiac output measurement by the 
      NICO(2) monitor agree well with TD under steady-state conditions but after CBP 
      the agreement was too small. Combining Qpc(NICO(2)) and Qt(TD) does not offer a 
      reliable possibility for calculating intrapulmonary shunt.
FAU - Neuhauser, C
AU  - Neuhauser C
AD  - Abteilung Anaesthesiologie, Intensivmedizin, Schmerztherapie, 
      Universitatsklinikum Giessen, Germany.
FAU - Muller, M
AU  - Muller M
FAU - Brau, M
AU  - Brau M
FAU - Scholz, S
AU  - Scholz S
FAU - Boning, O
AU  - Boning O
FAU - Roth, P
AU  - Roth P
FAU - Hempelmann, G
AU  - Hempelmann G
LA  - ger
PT  - Clinical Trial
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - "Partielle CO(2)-Ruckatmungstechnik" versus Thermodilution Bestimmung des 
      Herzzeitvolumens vor und nach Eingriffen mit extrakorporaler Zirkulation.
PL  - Germany
TA  - Anaesthesist
JT  - Der Anaesthesist
JID - 0370525
RN  - 142M471B3J (Carbon Dioxide)
SB  - IM
MH  - Algorithms
MH  - *Anesthesia, Closed-Circuit
MH  - Carbon Dioxide/*metabolism
MH  - Cardiac Output/*physiology
MH  - *Extracorporeal Circulation
MH  - Hemodynamics
MH  - Humans
MH  - Monitoring, Intraoperative/*methods
MH  - Postoperative Period
MH  - Pulmonary Circulation/*physiology
MH  - Pulmonary Wedge Pressure
MH  - Reproducibility of Results
MH  - *Thermodilution
EDAT- 2002/10/23 04:00
MHDA- 2002/12/11 04:00
CRDT- 2002/10/23 04:00
PHST- 2002/10/23 04:00 [pubmed]
PHST- 2002/12/11 04:00 [medline]
PHST- 2002/10/23 04:00 [entrez]
AID - 10.1007/s00101-002-0354-1 [doi]
PST - ppublish
SO  - Anaesthesist. 2002 Aug;51(8):625-33. doi: 10.1007/s00101-002-0354-1.