PMID- 12392300
OWN - NLM
STAT- MEDLINE
DCOM- 20030710
LR  - 20161018
IS  - 1434-6621 (Print)
IS  - 1434-6621 (Linking)
VI  - 40
IP  - 8
DP  - 2002 Aug
TI  - Comparative measurement of N-terminal pro-brain natriuretic peptide and brain 
      natriuretic peptide in ambulatory patients with heart failure.
PG  - 761-3
AB  - It is not clear whether brain natriuretic peptide (BNP) or N-terminal proBNP 
      (NT-proBNP) is superior as a diagnostic and prognostic indicator in cardiac 
      diseases. Here, we compare the clinical correlations of both peptides in a 
      population of 92 ambulatory patients with heart failure, using a well-established 
      immunoradiometric assay (IRMA) for BNP and an automated electrochemiluminescence 
      immunoassay for NT-proBNP. The analytical correlation between the two peptides 
      was satisfactory over a wide range of concentrations (1-686 pM for BNP) with the 
      equation: NT-proBNP = 3.48 x BNP -19 and a correlation coefficient r2=0.94. In 
      addition, the concentration of both peptides increased in a similar fashion 
      according to the severity of the disease New York Heart Association (NYHA) 
      functional class, left ventricular ejection fraction, etiology) and age; for 
      instance, the ratios between median levels measured in NYHA class III vs. class 
      II patients were comparable for BNP (383 vs. 16 pM, ratio 24) and NT-proBNP (1306 
      vs. 57 pM, ratio 23). We conclude that N-terminal proBNP, as assayed in the 
      present study, correlates equally to BNP with clinical variables in patients with 
      heart failure.
FAU - Masson, Serge
AU  - Masson S
AD  - Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario 
      Negri, Milan, Italy.
FAU - Vago, Tarcisio
AU  - Vago T
FAU - Baldi, Gabriella
AU  - Baldi G
FAU - Salio, Monica
AU  - Salio M
FAU - De Angelis, Noeleen
AU  - De Angelis N
FAU - Nicolis, Enrico
AU  - Nicolis E
FAU - Maggioni, Aldo P
AU  - Maggioni AP
FAU - Latini, Roberto
AU  - Latini R
FAU - Norbiato, Guido
AU  - Norbiato G
FAU - Bevilacqua, Maurizio
AU  - Bevilacqua M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
RN  - 0 (Biomarkers)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Heart Failure/blood/*diagnosis
MH  - Humans
MH  - Immunoradiometric Assay
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - Nerve Tissue Proteins/*blood
MH  - Peptide Fragments/*blood
MH  - Prognosis
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
EDAT- 2002/10/24 04:00
MHDA- 2003/07/11 05:00
CRDT- 2002/10/24 04:00
PHST- 2002/10/24 04:00 [pubmed]
PHST- 2003/07/11 05:00 [medline]
PHST- 2002/10/24 04:00 [entrez]
AID - 10.1515/CCLM.2002.130 [doi]
PST - ppublish
SO  - Clin Chem Lab Med. 2002 Aug;40(8):761-3. doi: 10.1515/CCLM.2002.130.