PMID- 12392776
OWN - NLM
STAT- MEDLINE
DCOM- 20030110
LR  - 20190910
IS  - 0197-4580 (Print)
IS  - 0197-4580 (Linking)
VI  - 23
IP  - 5
DP  - 2002 Sep-Oct
TI  - The glucocorticoid paradox of caloric restriction in slowing brain aging.
PG  - 707-17
AB  - Glucocorticoids have a bimodal effect on cognition, hippocampal pyramidal neurons 
      and long-term potentiation (LTP). Transient increases in glucocorticoids improve 
      performance at spatial memory tasks and facilitate synaptic efficacy, depending 
      on the context. On the other hand, long-term elevations of glucocorticoids are 
      associated with decreased cognitive performance, attenuated synaptic efficacy and 
      neuronal atrophy. Elevation of glucocorticoids during aging is also associated 
      with mild cognitive impairment and hippocampal atrophy. Caloric restriction (CR), 
      a dietary manipulation which extends life-span in rodents, also increases free 
      plasma corticosterone. Recent data suggests that CR attenuates many brain aging 
      changes and increases resistance of neurons to toxins and injury. Thus, a paradox 
      may be considered: if CR causes chronic elevation of glucocorticoids, and if 
      glucocorticoids can increase the risk of neurodegeneration, how can CR be 
      neuroprotective. We suggest that the neuroprotective effects of CR outweigh the 
      deleterious effects of glucocorticoids. The neuroprotective effects of CR that 
      are discussed here include decreased plasma glucose, attenuated free radical 
      generation, alterations of the vasculature, increased expression of heat shock 
      proteins and neurotrophic factors, and attenuation of age-related glial 
      activation.
CI  - Copyright 2002 Elsevier Science Inc.
FAU - Patel, N V
AU  - Patel NV
AD  - Department of Biological Sciences, Andrus Gerontology Center, University of 
      Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA.
FAU - Finch, C E
AU  - Finch CE
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 0 (Glucocorticoids)
SB  - IM
MH  - Aged
MH  - Aging/*metabolism/pathology
MH  - Animals
MH  - Brain/*metabolism/pathology
MH  - *Caloric Restriction
MH  - Glucocorticoids/*metabolism
MH  - Humans
RF  - 118
EDAT- 2002/10/24 04:00
MHDA- 2003/01/11 04:00
CRDT- 2002/10/24 04:00
PHST- 2002/10/24 04:00 [pubmed]
PHST- 2003/01/11 04:00 [medline]
PHST- 2002/10/24 04:00 [entrez]
AID - S0197458002000179 [pii]
AID - 10.1016/s0197-4580(02)00017-9 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2002 Sep-Oct;23(5):707-17. doi: 10.1016/s0197-4580(02)00017-9.