PMID- 12392777
OWN - NLM
STAT- MEDLINE
DCOM- 20030110
LR  - 20220311
IS  - 0197-4580 (Print)
IS  - 0197-4580 (Linking)
VI  - 23
IP  - 5
DP  - 2002 Sep-Oct
TI  - A review of specific dietary antioxidants and the effects on biochemical 
      mechanisms related to neurodegenerative processes.
PG  - 719-35
AB  - Aging is a major risk factor for neurodegenerative diseases including Alzheimer's 
      disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). 
      An unbalanced overproduction of reactive oxygen species (ROS) may give rise to 
      oxidative stress which can induce neuronal damage, ultimately leading to neuronal 
      death by apoptosis or necrosis. A large body of evidence indicates that oxidative 
      stress is involved in the pathogenesis of AD, PD, and ALS. An increasing number 
      of studies show that nutritional antioxidants (especially Vitamin E and 
      polyphenols) can block neuronal death in vitro, and may have therapeutic 
      properties in animal models of neurodegenerative diseases including AD, PD, and 
      ALS. Moreover, clinical data suggest that nutritional antioxidants might exert 
      some protective effect against AD, PD, and ALS. In this paper, the biochemical 
      mechanisms by which nutritional antioxidants can reduce or block neuronal death 
      occurring in neurodegenerative disorders are reviewed. Particular emphasis will 
      be given to the role played by the nuclear transcription factor-kappaB 
      (NF-kappaB) in apoptosis, and in the pathogenesis of neurodegenerative disorders, 
      such as AD, PD, and ALS. The effects of ROS and antioxidants on NF-kappaB 
      function and their relevance in the pathophysiology of neurodegenerative diseases 
      will also be examined.
CI  - Copyright 2002 Elsevier Science Inc.
FAU - Esposito, Ennio
AU  - Esposito E
AD  - Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, 66030 
      Santa Maria Imbaro, Chieti, Italy. esposito@cmns.mnegri.it
FAU - Rotilio, Domenico
AU  - Rotilio D
FAU - Di Matteo, Vincenzo
AU  - Di Matteo V
FAU - Di Giulio, Camillo
AU  - Di Giulio C
FAU - Cacchio, Marisa
AU  - Cacchio M
FAU - Algeri, Sergio
AU  - Algeri S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 0 (Antioxidants)
SB  - IM
MH  - Aged
MH  - Antioxidants/*therapeutic use
MH  - Brain/*metabolism
MH  - Diet
MH  - Humans
MH  - Neurodegenerative Diseases/*diet therapy/*metabolism
RF  - 292
EDAT- 2002/10/24 04:00
MHDA- 2003/01/11 04:00
CRDT- 2002/10/24 04:00
PHST- 2002/10/24 04:00 [pubmed]
PHST- 2003/01/11 04:00 [medline]
PHST- 2002/10/24 04:00 [entrez]
AID - S0197458002000787 [pii]
AID - 10.1016/s0197-4580(02)00078-7 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2002 Sep-Oct;23(5):719-35. doi: 10.1016/s0197-4580(02)00078-7.