PMID- 12392855
OWN - NLM
STAT- MEDLINE
DCOM- 20030411
LR  - 20190906
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 63
IP  - 11
DP  - 2002 Nov
TI  - Association of high HIV-1 RNA levels and homozygosity at HLA class II DRB1 in 
      adults coinfected with Mycobacterium tuberculosis in Harare, Zimbabwe.
PG  - 1026-32
AB  - HIV-1 mRNA levels (virus load) were quantified for 191 pulmonary tuberculosis 
      (TB) patients and 132 HIV-1 seropositive controls. Human leukocyte antigen (HLA) 
      class I and II genes were typed for 188 patients and 121 HIV-1 seropositive 
      controls. The mean log virus load was higher among cases than HIV-1 seropositive 
      controls (p < 0.0001). Among the controls, mean log virus load was higher among 
      males than females (p = 0.04). There was no association between virus load and 
      homozygosity at HLA class I and II among the controls. In contrast, among the 
      cases, HLA-DRB1 homozygosity was associated with high virus load (p = 0.008), 
      conferring risk for rapid progression to AIDS, thus lending support to the 
      heterozygote advantage hypothesis. The observed decreased virus load in HLA-DRB-1 
      heterozygotes may be due to a better control of M. tb. infection in the context 
      of HIV-1 disease.
FAU - Zijenah, Lynn S
AU  - Zijenah LS
AD  - Department of Immunology, University of Zimbabwe Medical School, Harare, 
      Zimbabwe. lzijenah@healthnet.zw
FAU - Hartogensis, Wendy E
AU  - Hartogensis WE
FAU - Katzenstein, David A
AU  - Katzenstein DA
FAU - Tobaiwa, Ocean
AU  - Tobaiwa O
FAU - Mutswangwa, Junior
AU  - Mutswangwa J
FAU - Mason, Peter R
AU  - Mason PR
FAU - Louie, Leslie G
AU  - Louie LG
LA  - eng
GR  - R01 AI 40019/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*immunology/virology
MH  - Adult
MH  - Aged
MH  - CD4 Lymphocyte Count
MH  - Female
MH  - *Genes, MHC Class II
MH  - HIV-1/genetics/*isolation & purification
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Homozygote
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - RNA, Viral/*analysis
MH  - Tuberculin Test
MH  - Tuberculosis/*immunology/virology
MH  - Viral Load
MH  - Zimbabwe
EDAT- 2002/10/24 04:00
MHDA- 2003/04/12 05:00
CRDT- 2002/10/24 04:00
PHST- 2002/10/24 04:00 [pubmed]
PHST- 2003/04/12 05:00 [medline]
PHST- 2002/10/24 04:00 [entrez]
AID - S0198885902006845 [pii]
AID - 10.1016/s0198-8859(02)00684-5 [doi]
PST - ppublish
SO  - Hum Immunol. 2002 Nov;63(11):1026-32. doi: 10.1016/s0198-8859(02)00684-5.